高雄醫學大學脂質科學暨老化研究中心

2024年

1.	Upregulated Small-Conductance Calcium-Activated Potassium Currents Contribute to Atrial Arrhythmogenesis in High-Fat Feeding Mice. Tsai WC, Lin YH, Kuo CH, Jhuo SJ, Shih RY, Wu CC, Liu IH, Huang TC, Liu RM, Lin TH, Su HM, Lai WT, Lee CH, Wu BN, Lin SF, Lee HC. Europace. 2023 Dec 28;26(1):euae004. doi: 10.1093/europace/euae004. PMID: 38195705Free PMC article.
2.	Female showed favorable left ventricle hypertrophy regression during post-TAVR follow-up. Chiu CA, Chen PR, Li YJ, Hsieh CC, Yu HC, Chiu CC, Huang JW, Chu CY, Lin TH, Lee HC. Kaohsiung J Med Sci. 2024 Feb 8. doi: 10.1002/kjm2.12808. Epub ahead of print. PMID: 38332510. Free PMC article.
3.	Trends and Changes in Intensive Care Use for Patients With Heart Failure in the Last Month of Life. Chou PL, Lin PC, Lin CC, Lee HC, Huang YT. Inquiry. 2024 Jan-Dec;61:469580241239143. doi: 10.1177/00469580241239143. PMID: 38506439 Free PMC article.

2023年

1.	An open-label randomized non-inferior study of generic-name and brand-name of propafenone for rhythm control in patients with paroxysmal atrial fibrillation. Chin CG, Hsieh YC, Lin WS, Lin YJ, Chiou CW, Lin TH, Huang CL, Hung Y, Lin YK, Chang SL, Yeh TC, Lee HC, Lai WT, Hsieh MH. J Chin Med Assoc. 2023 May 1;86(5):472-478. doi: 10.1097/JCMA.0000000000000903. PMID: 36800262 Free PMC article.
2.	Spondyloarthritis and nonbacterial thrombotic endocarditis as paraneoplastic manifestations in treatment-naive Burkitt lymphoma. Wang CY, Lee HC, Lin RJ, Tsai JJ. Int J Rheum Dis. 2023 Aug;26(8):1608-1611. doi: 10.1111/1756-185X.14651. PMID: 36938829 CASE REPORT.
3.	Nonbacterial thrombotic endocarditis as a paraneoplastic manifestation of newly diagnosed splenic large B cell lymphoma. Wang CY, Lee HC, Lin RJ, Tsai JJ. Kaohsiung Journal of Medical Sciences. 2023 Mar. doi.org/10.1002/kjm2.12677.
4.	Association of lipid composition and unsaturated fatty acids of VLDL with atrial remodeling in metabolic syndrome. Lee HC, Cheng WC, Ma WL, Lin YH, Shin SJ, Lin YH. Sci Rep. 2023 Apr 21;13(1):6575. doi: 10.1038/s41598-023-33757-0. PMID: 37085694 Free PMC article.
5.	Mitochondrial oxidative stress mediates bradyarrhythmia in leigh syndrome mitochondrial disease mice. Chen B, Daneshgar N, Lee HC, Song LS, Dai DF. Antioxidants (Basel). 2023 Apr 26;12(5):1001. doi: 10.3390/antiox12051001. PMID: 37237867 Free PMC article.

2022年

1.	Regorafenib for Taiwanese patients with unresectable hepatocellular carcinoma after sorafenib failure: Impact of alpha-fetoprotein levels. Hsu PY, Cheng TS, Chuang SC, Chang WT, Liang PC, Hsu CT, Wei YJ, Jang TY, Yeh ML, Huang CI, Lin YH, Wang CW, Hsieh MY, Hou NJ, Hsieh MH, Tsai YS, Ko YM, Lin CC, Chen KY, Dai CY, Lin ZY, Chen SC, Huang JF, Chuang WL, Huang CF, Yu ML. Int J Mol Sci. 2022 Jan;11(1):104-116. doi: 10.1002/cam4.4430. PMID: 34786871 Free PMC article.
2.	Long-term High-fat Diet Consumption Depletes Glial Cells and Tyrosine Hydroxylase-containing Neurons in the Brain of Middle-aged Rats. Chou MC, Lee HC, Liu YC, Yen PS, Liu CK, Chen CH, Hsieh TH, Chen SL. Int J Mol Sci. 2022 Jan 15;11(2):295. doi: 10.3390/cells11020295. PMID: 35053411Free PMC article.
3.	Clinical Observation of SGLT2 Inhibitor Therapy for Cardiac Arrhythmia and Related Cardiovascular Disease in Diabetic Patients with Controlled Hypertension. Jhuo SJ, Lin TH, Lin YH, Tsai WC, Liu IH, Wu BN, Lee KT, Lai WT. Int J Mol Sci. 2022 Feb 12;12(2):271. doi: 10.3390/jpm12020271. PMID: 35207759Free PMC article.
4.	Sofosbuvir/Velpatasvir for Hepatitis C Virus Infection: Real-World Effectiveness and Safety from a Nationwide Registry in Taiwan. Cheng PN, Mo LR, Chen CT, Chen CY, Huang CF, Kuo HT, Lo CC, Tseng KC, Huang YH, Tai CM, Peng CY, Bair MJ, Chen CH, Yeh ML, Lin CL, Lin CY, Lee PL, Chong LW, Hung CH, Chang TS, Huang JF, Yang CC, Hu JT, Lin CW, Wang CC, Su WW, Hsieh TY, Lin CL, Tsai WL, Lee TH, Chen GY, Wang SJ, Chang CC, Yang SS, Wu WC, Huang CS, Chou KH, Kao CN, Tsai PC, Liu CH, Lee MH, Cheng CY, Tsai MC, Liu CJ, Dai CY, Lin HC, Kao JH, Chuang WL, Yu ML; TACR investigators. Int J Mol Sci. 2022 Feb;11(1):485-500. doi: 10.1007/s40121-021-00576-7. PMID: 34967920 Free PMC article.
5.	Ledipasvir/sofosbuvir for HCV genotype 1, 2, 4e6 infection: Real-world evidence from a nationwide registry in Taiwan. Lo CC, Huang CF, Cheng PN, Tseng KC, Chen CY, Kuo HT, Huang YH, Tai CM, Peng CY, Bair MJ, Chen CH, Yeh ML, Lin CL, Lin CY, Lee PL, Chong LW, Hung CH, Chang TS, Huang JF, Yang CC, Hu JT, Lin CW, Chen CT, Wang CC, Su WW, Hsieh TY, Lin CL, Tsai WL, Lee TH, Chen GY, Wang SJ, Chang CC, Mo LR, Yang SS, Wu WC, Huang CS, Hsiung CK, Kao CN, Tsai PC, Liu CH, Lee MH, Liu CJ, Dai CY, Chuang WL, Lin HC, Kao JH, Yu ML; TACR investigators. Int J Mol Sci. 2022 Feb 2;S0929-6646(22)00032-8. doi: 10.1016/j.jfma.2022.01.012. PMID: 35123849 Free PMC article.
6.	Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL). Huang JK, Lee HC. Int J Mol Sci. 2022 Apr 13;23(8):4300. doi: 10.3390/ijms23084300. PMID: 35457118Free PMC article. Review.
7.	Exploiting exercise electrocardiography to improve early diagnosis of atrial fibrillation with deep learning neural networks. Lee HC, Chen CY, Lee SJ, Lee MC, Tsai CY, Chen ST, Li YJ. Int J Mol Sci. 2022 Jul;146:105584. doi: 10.1016/j.compbiomed.2022.105584. PMID: 35551013 Review.
8.	Skin sympathetic nerve activity and ventricular arrhythmias in acute coronary syndrome. Huang TC, Lin SJ, Chen CJ, Jhuo SJ, Chang CW, Lin SC, Chi NY, Chou LF, Tai LH, Liu YH, Lin TH, Liao WS, Kao PH, Cheng MC, Hsu PC, Lee CS, Lin YH, Lee HC, Lu YH, Yen HW, Lin TH, Su HM, Lai WT, Dai CY, Lee CH, Chen PS, Lin SF, Tsai WC. Heart Rhythm. 2022 Oct;19(10):1613-1619. doi: 10.1016/j.hrthm.2022.04.031. PMID: 35525422 Free PMC article.
9.	QTc Interval is Associated with Atrial Fibrillation in Individuals with Metabolic Syndrome Phenotype. Lee MC, Wang YT, Li YJ, Tsai CY, Chen ST, Jhuang WJ, Chang MC, Chien MY, Lee HC. Int J Gen Med. 2022 Jul 15;15:6189-6198. doi: 10.2147/IJGM.S361705. PMID: 35874912 Free PMC article.
10.	Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: implications for disease progression and mechanistic insights. Lee HC, Akhmedov A, Chen CH. Front Cardiovasc Med. 2022 Oct 4;9:993633. doi: 10.3389/fcvm.2022.993633. PMID: 36267630 Review.

2021年

1.	New Insight into the Effects of Metformin on Diabetic Retinopathy, Aging and Cancer: Nonapoptotic Cell Death, Immunosuppression, and Effects beyond the AMPK Pathway. Hsu SK, Cheng KC, Mgbeahuruike MO, Lin YH, Wu CY, Wang HD, Yen CH, Chiu CC, Sheu SJ. Int J Mol Sci. 2021 Aug 31;22(17):9453. doi: 10.3390/ijms22179453. PMID: 34502359 Free PMC article. Review.
2.	Add-on memantine may improve cognitive functions and attenuate inflammation in middle- to old-aged bipolar II disorder patients. Lu RB, Wang TY, Lee SY, Chang YH, Chen SL, Tsai TY, Chen PS, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS. J Affect Disord. 2021 Jan 15;279:229-238. doi: 10.1016/j.jad.2020.10.003. Epub 2020 Oct 6. PMID: 33069121 Clinical Trial.
3.	Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, Teng YN, Lin YH, Yen CH, Chiu CC. Theranostics. 2021 Aug 12;11(18):8813-8835. doi: 10.7150/thno.62521. eCollection 2021. PMID: 34522213 Free PMC article. Review.
4.	The Role of Oxidative Stress and Autophagy in Blue-Light-Induced Damage to the Retinal Pigment Epithelium in Zebrafish In Vitro and In Vivo. Cheng KC, Hsu YT, Liu W, Huang HL, Chen LY, He CX, Sheu SJ, Chen KJ, Lee PY, Lin YH, Chiu CC. Int J Mol Sci. 2021 Jan 29;22(3):1338. doi: 10.3390/ijms22031338. PMID: 33572787 Free PMC article.
5.	Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues. Jang TY, Wei YJ, Yeh ML, Liu SF, Hsu CT, Hsu PY, Liu TW, Lin YH, Liang PC, Hsieh MH, Ko YM, Tsai YS, Chen KY, Lin CC, Tsai PC, Wang SC, Huang CI, Lin ZY, Chen SC, Chuang WL, Huang JF, Dai CY, Huang CF, Yu ML. J Formos Med Assoc. 2021 Jan;120(1 Pt 2):303-310. doi: 10.1016/j.jfma.2020.10.002. Epub 2020 Oct 24. PMID: 33109431
6.	Genotype distribution, clinical characteristics, and racial differences observed in chronic hepatitis C patients in Pingtung, Taiwan. Jang TY, Liang PC, Liu TW, Wei YJ, Yeh ML, Hsu CT, Hsu PY, Lin YH, Hsieh MH, Huang CI, Huang CF, Lin ZY, Chen SC, Huang JF, Dai CY, Yu ML, Chuang WL. J Chin Med Assoc. 2021 Mar 1;84(3):255-260. doi: 10.1097/JCMA.0000000000000478. PMID: 33433134
7.	Hepatitis b infection: progress in identifying patients most likely to respond to peginterferon alfa. Yeh ML, Huang JF, Yu ML, Chuang WL. Expert Rev Gastroenterol Hepatol. 2021 Apr;15(4):427-435. doi: 10.1080/17474124.2021.1866985. Epub 2020 Dec 24. PMID: 33338385
8.	Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice. Lin YS, Liu CK, Lee HC, Chou MC, Ke LY, Chen CH, Chen SL. Sci Rep. 2021 Mar 16;11(1):6013. doi: 10.1038/s41598-021-85502-0. PMID: 33727609 Free PMC article.
9.	Characteristics and Survival Outcomes of Hepatocellular Carcinoma Developed after HCV SVR. Yeh ML, Liang PC, Tsai PC, Wang SC, Leong J, Ogawa E, Jun DW, Tseng CH, Landis C, Tanaka Y, Huang CF, Hayashi J, Hsu YC, Huang JF, Dai CY, Chuang WL, Nguyen MH, Yu ML. Cancers (Basel). 2021 Jul 9;13(14):3455. doi: 10.3390/cancers13143455. PMID: 34298669 Free PMC article.
10.	Concordance of SVR12, SVR24 and SVR durability in Taiwanese chronic hepatitis C patients with direct-acting antivirals. Lin CP, Liang PC, Huang CI, Yeh ML, Hsu PY, Hsu CT, Wei YJ, Liu TW, Hsieh MY, Hou NJ, Jang TY, Lin YH, Wang CW, Lin ZY, Chen SC, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. PLoS One. 2021 Feb 4;16(2):e0245479. doi: 10.1371/journal.pone.0245479. eCollection 2021. PMID: 33539408 Free PMC article.
11.	Seroreversion of hepatitis B surface antigen among subjects with resolved hepatitis B virus infection: A community-based cohort study. Yeh ML, Liang PC, Huang CI, Hsieh MH, Lin YH, Jang TY, Wei YJ, Hsu PY, Hsu CT, Wang CW, Hsieh MY, Lin ZY, Chen SC, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. J Gastroenterol Hepatol. 2021 Jul 28. doi: 10.1111/jgh.15640. Online ahead of print. PMID: 34318943
12.	Corrigendum to "More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder" [Psychoneuroendocrinology (2017; 85, 42-48). Wang TY, Lee SY, Hu MC, Chen SL, Chang YH, Chu CH, Lin SH, Li CL, Wang LJ, Chen PS, Chen SH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Psychoneuroendocrinology. 2021 Sep;131:105233. doi: 10.1016/j.psyneuen.2021.105233. Epub 2021 Jul 7. PMID: 34243962 No abstract available.

2020年

1.	Identifying the Therapeutic Significance of Mesenchymal Stem Cells. Mishra VK, Shih HH, Parveen F, Lenzen D, Ito E, Chan TF, Ke LY. Cells. 2020 May 6;9(5):1145. doi: 10.3390/cells9051145. PMID: 32384763 Free PMC article. Review.
2.	The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome. Lee HC, Lin YH. Int J Mol Sci. 2020 Jan 30;21(3):891. doi: 10.3390/ijms21030891. PMID: 32019138 Free PMC article. Review.
3.	Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. Hsu WL, Tsai MH, Wu CY, Liang JL, Lu JH, Kahle JS, Yu HS, Yen CJ, Yen CT, Hsieh YC, Huang YY, Lin LC, Tsai TF, Chen CH, Yoshioka T. Aging Cell. 2020 Jan;19(1):e13075. doi: 10.1111/acel.13075. Epub 2019 Nov 21. PMID: 31755176 Free PMC article.
4.	Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration. Lin YH, Kang L, Feng WH, Cheng TL, Tsai WC, Huang HT, Lee HC, Chen CH. Int J Mol Sci. 2020 Jul 5;21(13):4770. doi: 10.3390/ijms21134770. PMID: 32635662 Free PMC article. Review.
5.	Cure or curd: Modification of lipid profiles and cardio-cerebrovascular events after hepatitis C virus eradication. Huang CF, Dai CY, Yeh ML, Huang CI, Lee HC, Lai WT, Liang PC, Lin YH, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Huang JF, Chuang WL, Yu ML. Kaohsiung J Med Sci. 2020 Nov;36(11):920-928. doi: 10.1002/kjm2.12275. Epub 2020 Jul 9. PMID: 32643842
6.	Activation of acid-sensing ion channel 3 by lysophosphatidylcholine 16:0 mediates psychological stress-induced fibromyalgia-like pain. Hung CH, Lee CH, Tsai MH, Chen CH, Lin HF, Hsu CY, Lai CL, Chen CC. Ann Rheum Dis. 2020 Dec;79(12):1644-1656. doi: 10.1136/annrheumdis-2020-218329. Epub 2020 Sep 9. PMID: 32907805 Free PMC article.
7.	The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome. Lee HC, Shin SJ, Huang JK, Lin MY, Lin YH, Ke LY, Jiang HJ, Tsai WC, Chao MF, Lin YH. Lipids Health Dis. 2020 Sep 22;19(1):210. doi: 10.1186/s12944-020-01386-5. PMID: 32962696 Free PMC article. Clinical Trial.
8.	Increased APOE glycosylation plays a key role in the atherogenicity of L5 low-density lipoprotein. Ke LY, Chan HC, Chen CC, Chang CF, Lu PL, Chu CS, Lai WT, Shin SJ, Liu FT, Chen CH. FASEB J. 2020 Jul;34(7):9802-9813. doi: 10.1096/fj.202000659R. Epub 2020 Jun 5. PMID: 32501643
9.	miR-26a attenuates cardiac apoptosis and fibrosis by targeting ataxia-telangiectasia mutated in myocardial infarction. Chiang MH, Liang CJ, Lin LC, Yang YF, Huang CC, Chen YH, Kao HL, Chen YC, Ke SR, Lee CW, Lin MS, Chen YL. J Cell Physiol. 2020 Sep;235(9):6085-6102. doi: 10.1002/jcp.29537. Epub 2020 Jan 28. PMID: 31990056
10.	Discoidin domain receptor 1 regulates endochondral ossification through terminal differentiation of chondrocytes. Chou LY, Chen CH, Lin YH, Chuang SC, Chou HC, Lin SY, Fu YC, Chang JK, Ho ML, Wang CZ. FASEB J. 2020 Apr;34(4):5767-5781. doi: 10.1096/fj.201901852RR. Epub 2020 Mar 3. PMID: 32128899
11.	Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome. Lin HL, Lin SH, Shen KP, Chan HC, Tseng YH, Yen HW, Law SH, Ke LY. J Food Biochem. 2020 Feb;44(2):e13129. doi: 10.1111/jfbc.13129. Epub 2019 Dec 17. PMID: 31846084
12.	The applicability of non-invasive methods for assessing liver fibrosis in hemodialysis patients with chronic hepatitis C. Lee JJ, Wei YJ, Lin MY, Niu SW, Hsu PY, Huang JC, Jang TY, Yeh ML, Huang CI, Liang PC, Lin YH, Hsieh MY, Hsieh MH, Chen SC, Dai CY, Lin ZY, Chen SC, Huang JF, Chang JM, Hwang SJ, Huang CF, Chiu YW, Chuang WL, Yu ML. PLoS One. 2020 Nov 20;15(11):e0242601. doi: 10.1371/journal.pone.0242601. eCollection 2020. PMID: 33216807 Free PMC article.
13.	Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects. Kakino A, Fujita Y, Ke LY, Chan HC, Tsai MH, Dai CY, Chen CH, Sawamura T. J Lipid Res. 2020 Nov 21;62:100001. doi: 10.1194/jlr.RA120000767. Online ahead of print. PMID: 33410750 Free PMC article.
14.	ALDH2 Gene: Its Effects on the Neuropsychological Functions in Patients with Opioid Use Disorder Undergoing Methadone Maintenance Treatment. Lee PW, Wang TY, Chang YH, Lee SY, Chen SL, Wang ZC, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Clin Psychopharmacol Neurosci. 2020 Feb 29;18(1):136-144. doi: 10.9758/cpn.2020.18.1.136. PMID: 31958914 Free PMC article.
15.	Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade. Chen CH, Ke LY, Chan HC, Chu CS, Lee AS, Lin KD, Lee MY, Hsiao PJ, Chen CH, Shin SJ. J Diabetes Investig. 2020 May;11(3):535-544. doi: 10.1111/jdi.13158. Epub 2019 Nov 6. PMID: 31597015 Free PMC article.
16.	Clusters of Circulating let-7 Family Tumor Suppressors Are Associated with Clinical Characteristics of Chronic Hepatitis C. Tsai YS, Yeh ML, Tsai PC, Huang CI, Huang CF, Hsieh MH, Liu TW, Lin YH, Liang PC, Lin ZY, Chen SC, Huang JF, Chuang WL, Dai CY, Yu ML. Int J Mol Sci. 2020 Jul 13;21(14):4945. doi: 10.3390/ijms21144945. PMID: 32668728 Free PMC article.
17.	Improvement of hyperuricemia in chronic hepatitis C patients receiving directly acting antiviral agents. Jang TY, Huang CI, Yeh ML, Liang PC, Tsai PC, Lin YH, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Huang JF, Dai CY, Huang CF, Chuang WL, Yu ML. J Gastroenterol Hepatol. 2020 Mar;35(3):473-481. doi: 10.1111/jgh.14835. Epub 2019 Sep 10. PMID: 31414504
18.	Genetic Diversity and Phylogenetic Analysis of Human Bocavirus 2 in Pediatric Patients with Acute Gastroenteritis in Taiwan. Lin MY, Chan HC, Chi H, Chiu SC, Nora-Krukle Z, Rasa-Dzelzkaleja S, Vilmane A, Murovska M, Lin JH, Liu HF. Int J Environ Res Public Health. 2020 Feb 8;17(3):1086. doi: 10.3390/ijerph17031086. PMID: 32046345 Free PMC article.
19.	Serial serologic changes of hepatitis D virus in chronic hepatitis B patients receiving nucleos(t)ides analogues therapy. Jang TY, Wei YJ, Hsu CT, Hsu PY, Liu TW, Lin YH, Liang PC, Hsieh MH, Ko YM, Tsai YS, Chen KY, Lin CC, Tsai PC, Wang SC, Huang CI, Yeh ML, Lin ZY, Chen SC, Chuang WL, Huang JF, Dai CY, Huang CF, Yu ML. J Gastroenterol Hepatol. 2020 Nov;35(11):1886-1892. doi: 10.1111/jgh.15061. Epub 2020 Apr 16. PMID: 32247291
20.	Discoidin Domain Receptor 1 Regulates Runx2 during Osteogenesis of Osteoblasts and Promotes Bone Ossification via Phosphorylation of p38. Chou LY, Chen CH, Chuang SC, Cheng TL, Lin YH, Chou HC, Fu YC, Wang YH, Wang CZ. Int J Mol Sci. 2020 Sep 29;21(19):7210. doi: 10.3390/ijms21197210. PMID: 33003599 Free PMC article.
21.	Ribavirin facilitates early viral kinetics in chronic hepatitis C patients receiving daclatasvir/asunaprevir. Huang CF, Yeh ML, Huang CI, Liang PC, Lin YH, Hsieh MY, Chen KY, Ko YM, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Yu ML. J Gastroenterol Hepatol. 2020 Jan;35(1):151-156. doi: 10.1111/jgh.14815. Epub 2019 Aug 15. PMID: 31373037
22.	Add-on memantine may improve cognitive functions and attenuate inflammation in middle- to old-aged bipolar II disorder patients. Lu RB, Wang TY, Lee SY, Chang YH, Chen SL, Tsai TY, Chen PS, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS. J Affect Disord. 2021 Jan 15;279:229-238. doi: 10.1016/j.jad.2020.10.003. Epub 2020 Oct 6. PMID: 33069121 Clinical Trial.
23.	Role of hepatitis D virus in persistent alanine aminotransferase abnormality among chronic hepatitis B patients treated with nucleotide/nucleoside analogues. Jang TY, Wei YJ, Yeh ML, Liu SF, Hsu CT, Hsu PY, Liu TW, Lin YH, Liang PC, Hsieh MH, Ko YM, Tsai YS, Chen KY, Lin CC, Tsai PC, Wang SC, Huang CI, Lin ZY, Chen SC, Chuang WL, Huang JF, Dai CY, Huang CF, Yu ML. J Formos Med Assoc. 2021 Jan;120(1 Pt 2):303-310. doi: 10.1016/j.jfma.2020.10.002. Epub 2020 Oct 24. PMID: 33109431
24.	Hepatitis b infection: progress in identifying patients most likely to respond to peginterferon alfa. Yeh ML, Huang JF, Yu ML, Chuang WL. Expert Rev Gastroenterol Hepatol. 2021 Apr;15(4):427-435. doi: 10.1080/17474124.2021.1866985. Epub 2020 Dec 24. PMID: 33338385

2019年

1.	An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases. Law SH, Chan ML, Marathe GK, Parveen F, Chen CH, Ke LY. Int J Mol Sci. 2019 Mar 6;20(5):1149. doi: 10.3390/ijms20051149. PMID: 30845751 Free PMC article. Review.
2.	The sodium-glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats. Lee HC, Shiou YL, Jhuo SJ, Chang CY, Liu PL, Jhuang WJ, Dai ZK, Chen WY, Chen YF, Lee AS. Cardiovasc Diabetol. 2019 Apr 1;18(1):45. doi: 10.1186/s12933-019-0849-6. PMID: 30935417 Free PMC article.
3.	O-GlcNAcylation disrupts STRA6-retinol signals in kidneys of diabetes. Chen CH, Lin KD, Ke LY, Liang CJ, Kuo WC, Lee MY, Lee YL, Hsiao PJ, Hsu CC, Shin SJ. Biochim Biophys Acta Gen Subj. 2019 Jun;1863(6):1059-1069. doi: 10.1016/j.bbagen.2019.03.014. Epub 2019 Mar 21. PMID: 30905621
4.	Nociceptive transient receptor potential canonical 7 (TRPC7) mediates aging-associated tumorigenesis induced by ultraviolet B. Hsu WL, Tsai MH, Wu CY, Liang JL, Lu JH, Kahle JS, Yu HS, Yen CJ, Yen CT, Hsieh YC, Huang YY, Lin LC, Tsai TF, Chen CH, Yoshioka T. Aging Cell. 2020 Jan;19(1):e13075. doi: 10.1111/acel.13075. Epub 2019 Nov 21. PMID: 31755176 Free PMC article.
5.	Correlation between interleukin-6 levels and methadone maintenance therapy outcomes. Lu RB, Wang TY, Lee SY, Chen SL, Chang YH, See Chen P, Lin SH, Chu CH, Huang SY, Tzeng NS, Lee IH, Chin Chen K, Kuang Yang Y, Chen P, Chen SH, Hong JS. Drug Alcohol Depend. 2019 Nov 1;204:107516. doi: 10.1016/j.drugalcdep.2019.06.018. Epub 2019 Aug 30. PMID: 31513981 Free PMC article.
6.	Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats. Lin HT, Shiou YL, Jhuang WJ, Lee HC. J Vis Exp. 2019 Jan 31;(143). doi: 10.3791/59115. PMID: 30774131
7.	Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative stress and anti-inflammatory properties against metabolic syndrome. Lin HL, Lin SH, Shen KP, Chan HC, Tseng YH, Yen HW, Law SH, Ke LY. J Food Biochem. 2020 Feb;44(2):e13129. doi: 10.1111/jfbc.13129. Epub 2019 Dec 17. PMID: 31846084
8.	Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, Lin HL, Ke LY, Yen HW, Shen KP. J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13. PMID: 31353547
9.	Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade. Chen CH, Ke LY, Chan HC, Chu CS, Lee AS, Lin KD, Lee MY, Hsiao PJ, Chen CH, Shin SJ. J Diabetes Investig. 2020 May;11(3):535-544. doi: 10.1111/jdi.13158. Epub 2019 Nov 6. PMID: 31597015 Free PMC article.
10.	Improvement of hyperuricemia in chronic hepatitis C patients receiving directly acting antiviral agents. Jang TY, Huang CI, Yeh ML, Liang PC, Tsai PC, Lin YH, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Huang JF, Dai CY, Huang CF, Chuang WL, Yu ML. J Gastroenterol Hepatol. 2020 Mar;35(3):473-481. doi: 10.1111/jgh.14835. Epub 2019 Sep 10. PMID: 31414504
11.	Integrated care for methadone maintenance patients with hepatitis C virus infection. Tai CM, Yen YC, Bair MJ, Tseng CH, Chang TT, Huang CF, Yeh ML, Dai CY, Chuang WL, Yu ML, Huang JF. Kaohsiung J Med Sci. 2019 Aug;35(8):501-507. doi: 10.1002/kjm2.12086. Epub 2019 May 14. PMID: 31087764
12.	Ribavirin facilitates early viral kinetics in chronic hepatitis C patients receiving daclatasvir/asunaprevir. Huang CF, Yeh ML, Huang CI, Liang PC, Lin YH, Hsieh MY, Chen KY, Ko YM, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Yu ML. J Gastroenterol Hepatol. 2020 Jan;35(1):151-156. doi: 10.1111/jgh.14815. Epub 2019 Aug 15. PMID: 31373037
13.	Association between Negatively Charged Low-Density Lipoprotein L5 and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients. Chang CY, Chen CH, Chen YM, Hsieh TY, Li JP, Shen MY, Lan JL, Chen DY. J Clin Med. 2019 Feb 3;8(2):177. doi: 10.3390/jcm8020177. PMID: 30717448 Free PMC article.
14.	Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy. Yamakado S, Cho H, Inada M, Morikawa M, Jiang YH, Saito K, Nakaishi K, Watabe S, Takagi H, Kaneda M, Nakatsuma A, Ninomiya M, Imachi H, Arai T, Yoshimoto T, Murao K, Chang JH, Chen SM, Shih YC, Zeng MJ, Ke LY, Chen CH, Yoshimura T, Miura T, Ito E. BMJ Open Diabetes Res Care. 2019 May 30;7(1):e000661. doi: 10.1136/bmjdrc-2019-000661. eCollection 2019. PMID: 31245009 Free PMC article.
15.	A Novel Cell-Free, Non-Fluorescent Method to Measure LOX-1-Binding Activity Corresponding to The Functional Activity of HDL. Kakino A, Usami Y, Horiuchi S, Fujita Y, Kotani K, Chen CH, Okamura T, Sawamura T. J Atheroscler Thromb. 2019 Nov 1;26(11):947-958. doi: 10.5551/jat.47183. Epub 2019 Apr 3. PMID: 30944265 Free PMC article.
16.	Direct-acting antivirals response in hepatocellular carcinoma: Does the presence of hepatocellular carcinoma matter? Huang CF, Yu ML. Clin Mol Hepatol. 2019 Jun;25(2):168-171. doi: 10.3350/cmh.2018.1014. Epub 2019 Feb 11. PMID: 30739433 Free PMC article. Review.
17.	Equal treatment efficacy of direct-acting antivirals in patients with chronic hepatitis C and hepatocellular carcinoma? A prospective cohort study. Huang CF, Yeh ML, Huang CI, Liang PC, Lin YH, Hsieh MY, Wei YJ, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Yu ML. BMJ Open. 2019 May 5;9(5):e026703. doi: 10.1136/bmjopen-2018-026703. PMID: 31061041 Free PMC article.
18.	Immunoregulatory effects of very low density lipoprotein from healthy individuals and metabolic syndrome patients on glial cells. Li CL, Chu CH, Lee HC, Chou MC, Liu CK, Chen CH, Ke LY, Chen SL. Immunobiology. 2019 Sep;224(5):632-637. doi: 10.1016/j.imbio.2019.07.005. Epub 2019 Aug 3. PMID: 31402151
19.	Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes. Shiou YL, Lin HT, Ke LY, Wu BN, Shin SJ, Chen CH, Tsai WC, Chu CS, Lee HC. J Clin Med. 2019 Jun 20;8(6):881. doi: 10.3390/jcm8060881. PMID: 31226824 Free PMC article.
20.	Pretreatment Hepatitis B Viral Load Predicts Long-Term Hepatitis B Response After Anti-Hepatitis C Therapy in Hepatitis B/C Dual-Infected Patients. Yeh ML, Huang CI, Huang CF, Hsieh MH, Liu TW, Lin YH, Liang PC, Hsieh MY, Lin ZY, Chen SC, Huang JF, Kuo PL, Dai CY, Yu ML, Chuang WL. J Infect Dis. 2019 Apr 8;219(8):1224-1233. doi: 10.1093/infdis/jiy648. PMID: 30452671

2018年

1.	PM2.5-induced oxidative stress increases intercellular adhesion molecule-1 expression in lung epithelial cells through the IL-6/AKT/STAT3/NF-κB-dependent pathway. Liu CW, Lee TL, Chen YC, Liang CJ, Wang SH, Lue JH, Tsai JS, Lee SW, Chen SH, Yang YF, Chuang TY, Chen YL. Part Fibre Toxicol. 2018 Jan 12;15(1):4. doi: 10.1186/s12989-018-0240-x. PMID: 29329563 Free PMC article.
2.	Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats. Shen KP, Lin HL, Yen HW, Hsieh SL, An LM, Wu BN. Kaohsiung J Med Sci. 2018 Mar;34(3):142-149. doi: 10.1016/j.kjms.2017.11.003. Epub 2017 Nov 29. PMID: 29475461
3.	Effects of 5-HT and insulin on learning and memory formation in food-deprived snails. Aonuma H, Totani Y, Kaneda M, Nakamura R, Watanabe T, Hatakeyama D, Dyakonova VE, Lukowiak K, Ito E. Neurobiol Learn Mem. 2018 Feb;148:20-29. doi: 10.1016/j.nlm.2017.12.010. Epub 2017 Dec 30. PMID: 29294381
4.	2-Bromo-4'-methoxychalcone and 2-Iodo-4'-methoxychalcone Prevent Progression of Hyperglycemia and Obesity via 5'-Adenosine-Monophosphate-Activated Protein Kinase in Diet-Induced Obese Mice. Hsieh CT, Chang FR, Tsai YH, Wu YC, Hsieh TJ. Int J Mol Sci. 2018 Sep 14;19(9):2763. doi: 10.3390/ijms19092763. PMID: 30223438 Free PMC article.
5.	KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels. Lee CH, Dai ZK, Yen CT, Hsieh SL, Wu BN. Pharmacol Rep. 2018 Aug;70(4):746-752. doi: 10.1016/j.pharep.2018.02.017. Epub 2018 Feb 21. PMID: 29936361
6.	High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. Shiou YL, Huang IC, Lin HT, Lee HC. J Formos Med Assoc. 2018 Jul;117(7):621-631. doi: 10.1016/j.jfma.2017.08.008. Epub 2017 Sep 6. PMID: 28888352
7.	Correlation of cytokines, BDNF levels, and memory function in patients with opioid use disorder undergoing methadone maintenance treatment. Wang TY, Lee SY, Chang YH, Chen SL, Chen PS, Chu CH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Chen SH, Hong JS, Lu RB. Drug Alcohol Depend. 2018 Oct 1;191:6-13. doi: 10.1016/j.drugalcdep.2018.06.024. Epub 2018 Jul 25. PMID: 30071446 Free PMC article.
8.	ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study. Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Yang YH, Chen CS, Lu RB. Aust N Z J Psychiatry. 2018 Jul;52(7):680-689. doi: 10.1177/0004867417720517. Epub 2017 Aug 4. PMID: 28778129
9.	KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes. Liu CP, Chau PC, Chang CT, An LM, Yeh JL, Chen IJ, Wu BN. Molecules. 2018 Sep 23;23(10):2433. doi: 10.3390/molecules23102433. PMID: 30249030 Free PMC article.
10.	Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. Wang YC, Lee AS, Lu LS, Ke LY, Chen WY, Dong JW, Lu J, Chen Z, Chu CS, Chan HC, Kuzan TY, Tsai MH, Hsu WL, Dixon RAF, Sawamura T, Chang KC, Chen CH. Aging Cell. 2018 Aug;17(4):e12792. doi: 10.1111/acel.12792. Epub 2018 Jun 19. PMID: 29923368 Free PMC article.

2017年

1.	The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications. Akyol S, Lu J, Akyol O, Akcay F, Armutcu F, Ke LY, Chen CH. Trends Cardiovasc Med. 2017 May;27(4):239-246. doi: 10.1016/j.tcm.2016.11.002. Epub 2016 Nov 19. PMID: 28040327 Review.
2.	Air Pollution Particular Matter and Atherosclerosis. Lee HC, Lin TH. Acta Cardiol Sin. 2017 Nov;33(6):646-647. doi: 10.6515/ACS20170615A. PMID: 29167618 Free PMC article. No abstract available.
3.	VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Lu CW, Lo YH, Chen CH, Lin CY, Tsai CH, Chen PJ, Yang YF, Wang CH, Tan CH, Hou MF, Yuan SF. Cancer Lett. 2017 Mar 1;388:130-138. doi: 10.1016/j.canlet.2016.11.033. Epub 2016 Dec 7. PMID: 27940127
4.	Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats. Shen KP, Lin HL, Yen HW, Hsieh SL, An LM, Wu BN. Kaohsiung J Med Sci. 2018 Mar;34(3):142-149. doi: 10.1016/j.kjms.2017.11.003. Epub 2017 Nov 29. PMID: 29475461
5.	Very-Low-Density Lipoprotein of Metabolic Syndrome Modulates Gap Junctions and Slows Cardiac Conduction. Lee HC, Chen CC, Tsai WC, Lin HT, Shiao YL, Sheu SH, Wu BN, Chen CH, Lai WT. Sci Rep. 2017 Sep 21;7(1):12050. doi: 10.1038/s41598-017-11416-5. PMID: 28935953 Free PMC article.
6.	More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder. Wang TY, Lee SY, Hu MC, Chen SL, Chang YH, Chu CH, Lin SH, Li CL, Wang LJ, Chen PS, Chen SH, Huang SY, Tzeng NS, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Psychoneuroendocrinology. 2017 Nov;85:42-48. doi: 10.1016/j.psyneuen.2017.08.006. Epub 2017 Aug 5. PMID: 28810156
7.	Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression. Pu CM, Liu CW, Liang CJ, Yen YH, Chen SH, Jiang-Shieh YF, Chien CL, Chen YC, Chen YL. J Invest Dermatol. 2017 Jun;137(6):1353-1362. doi: 10.1016/j.jid.2016.12.030. Epub 2017 Feb 3. PMID: 28163069
8.	Effects of 5-HT and insulin on learning and memory formation in food-deprived snails. Aonuma H, Totani Y, Kaneda M, Nakamura R, Watanabe T, Hatakeyama D, Dyakonova VE, Lukowiak K, Ito E. Neurobiol Learn Mem. 2018 Feb;148:20-29. doi: 10.1016/j.nlm.2017.12.010. Epub 2017 Dec 30. PMID: 29294381
9.	6-Paradol and 6-Shogaol, the Pungent Compounds of Ginger, Promote Glucose Utilization in Adipocytes and Myotubes, and 6-Paradol Reduces Blood Glucose in High-Fat Diet-Fed Mice. Wei CK, Tsai YH, Korinek M, Hung PH, El-Shazly M, Cheng YB, Wu YC, Hsieh TJ, Chang FR. Int J Mol Sci. 2017 Jan 17;18(1):168. doi: 10.3390/ijms18010168. PMID: 28106738 Free PMC article.
10.	High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats. Shiou YL, Huang IC, Lin HT, Lee HC. J Formos Med Assoc. 2018 Jul;117(7):621-631. doi: 10.1016/j.jfma.2017.08.008. Epub 2017 Sep 6. PMID: 28888352
11.	Derivation and validation of a scoring system for predicting nonalcoholic steatohepatitis in Taiwanese patients with severe obesity. Tai CM, Yu ML, Tu HP, Huang CK, Hwang JC, Chuang WL. Surg Obes Relat Dis. 2017 Apr;13(4):686-692. doi: 10.1016/j.soard.2016.11.028. Epub 2016 Dec 7. PMID: 28089433
12.	MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling. Li YW, Chiang KY, Li YH, Wu SY, Liu W, Lin CR, Wu JL. PLoS One. 2017 May 22;12(5):e0177887. doi: 10.1371/journal.pone.0177887. eCollection 2017. PMID: 28531199 Free PMC article.
13.	ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study. Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Yang YH, Chen CS, Lu RB. Aust N Z J Psychiatry. 2018 Jul;52(7):680-689. doi: 10.1177/0004867417720517. Epub 2017 Aug 4. PMID: 28778129
14.	Metformin activates type I interferon signaling against HCV via activation of adenosine monophosphate-activated protein kinase. Tsai WL, Chang TH, Sun WC, Chan HH, Wu CC, Hsu PI, Cheng JS, Yu ML. Oncotarget. 2017 Aug 14;8(54):91928-91937. doi: 10.18632/oncotarget.20248. eCollection 2017 Nov 3. PMID: 29190886 Free PMC article.
15.	The treatment outcome and impact on blood transfusion demand of Peg-interferon/ribavirin in thalassemic patients with chronic hepatitis C. Liang PC, Lin PC, Huang CI, Huang CF, Yeh ML, Zeng YS, Hsu WY, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Chiou SS, Yu ML. J Formos Med Assoc. 2018 Jan;117(1):14-23. doi: 10.1016/j.jfma.2017.10.001. Epub 2017 Oct 31. PMID: 29097076
16.	Electronegative LDL-mediated cardiac electrical remodeling in a rat model of chronic kidney disease. Lee AS, Chen WY, Chan HC, Chung CH, Peng HY, Chang CM, Su MJ, Chen CH, Chang KC. Sci Rep. 2017 Jan 17;7:40676. doi: 10.1038/srep40676. PMID: 28094801 Free PMC article.
17.	Aliskiren Improves Ischemia- and Oxygen Glucose Deprivation-Induced Cardiac Injury through Activation of Autophagy and AMP-Activated Protein Kinase. Chiang MH, Liang CJ, Liu CW, Pan BJ, Chen WP, Yang YF, Lee IT, Tsai JS, Lee CW, Chen YL. Front Pharmacol. 2017 Nov 14;8:819. doi: 10.3389/fphar.2017.00819. eCollection 2017. PMID: 29184499 Free PMC article.
18.	Association of Renal Elasticity and Renal Function Progression in Patients with Chronic Kidney Disease Evaluated by Real-Time Ultrasound Elastography. Lin HY, Lee YL, Lin KD, Chiu YW, Shin SJ, Hwang SJ, Chen HC, Hung CC. Sci Rep. 2017 Feb 27;7:43303. doi: 10.1038/srep43303. PMID: 28240304 Free PMC article.
19.	Reactivation of hepatitis B in patients of chronic hepatitis C with hepatitis B virus infection treated with direct acting antivirals. Yeh ML, Huang CF, Hsieh MH, Ko YM, Chen KY, Liu TW, Lin YH, Liang PC, Hsieh MY, Lin ZY, Chen SC, Huang CI, Huang JF, Kuo PL, Dai CY, Yu ML, Chuang WL. J Gastroenterol Hepatol. 2017 Oct;32(10):1754-1762. doi: 10.1111/jgh.13771. PMID: 28230928
20.	Boceprevir-based triple therapy to rescue HCV genotype 1/HBV dually infected patients refractory to peginterferon plus ribavirin combination therapy in Taiwan. Hsieh MH, Yeh ML, Su TH, Liu TW, Huang CF, Huang CI, Wang SC, Huang JF, Dai CY, Kao JH, Chuang WL, Chen PJ, Liu CJ, Yu ML. J Formos Med Assoc. 2018 Jun;117(6):497-504. doi: 10.1016/j.jfma.2017.06.007. Epub 2017 Jul 8. PMID: 28694000
21.	Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-α-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-κB pathway. Liu CW, Sung HC, Lin SR, Wu CW, Lee CW, Lee IT, Yang YF, Yu IS, Lin SW, Chiang MH, Liang CJ, Chen YL. Sci Rep. 2017 Mar 24;7:44689. doi: 10.1038/srep44689. PMID: 28338009 Free PMC article.
22.	Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment. Yu ML, Huang CF, Yeh ML, Tsai PC, Huang CI, Hsieh MH, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL. Clin Cancer Res. 2017 Apr 1;23(7):1690-1697. doi: 10.1158/1078-0432.CCR-16-0921. Epub 2016 Oct 12. PMID: 27733478
23.	Electronegative Low-Density Lipoprotein L5 Induces Adipose Tissue Inflammation Associated With Metabolic Syndrome. Ke LY, Chan HC, Chan HC, Kalu FCU, Lee HC, Lin IL, Jhuo SJ, Lai WT, Tsao CR, Sawamura T, Dixon RA, Chen CH, Chu CS, Shin SJ. J Clin Endocrinol Metab. 2017 Dec 1;102(12):4615-4625. doi: 10.1210/jc.2017-01657. PMID: 29029093
24.	Pro-arrhythmogenic Effects of the V141M KCNQ1 Mutation in Short QT Syndrome and Its Potential Therapeutic Targets: Insights from Modeling. Lee HC, Rudy Y, Liang H, Chen CC, Luo CH, Sheu SH, Cui J. J Med Biol Eng. 2017 Oct;37(5):780-789. doi: 10.1007/s40846-017-0257-x. Epub 2017 Jul 5. PMID: 29213224 Free PMC article.
25.	Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress. Wu CY, Hsu WL, Tsai MH, Liang JL, Lu JH, Yen CJ, Yu HS, Noda M, Lu CY, Chen CH, Yan SJ, Yoshioka T. Sci Rep. 2017 Jun 15;7(1):3606. doi: 10.1038/s41598-017-03513-2. PMID: 28620198 Free PMC article.
26.	Human electronegative low-density lipoprotein modulates cardiac repolarization via LOX-1-mediated alteration of sarcolemmal ion channels. Lee AS, Xi Y, Lai CH, Chen WY, Peng HY, Chan HC, Chen CH, Chang KC. Sci Rep. 2017 Sep 7;7(1):10889. doi: 10.1038/s41598-017-10503-x. PMID: 28883612 Free PMC article.
27.	Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells. Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH, Wu BN. Chem Biol Interact. 2018 Jan 5;279:171-176. doi: 10.1016/j.cbi.2017.11.017. Epub 2017 Nov 26. PMID: 29183753
28.	The COMT Val158Met Polymorphism Is Associated With Response to Add-on Dextromethorphan Treatment in Bipolar Disorder. Lee SY, Chen SL, Wang TY, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Lu RB. J Clin Psychopharmacol. 2017 Feb;37(1):94-98. doi: 10.1097/JCP.0000000000000633. PMID: 27930497 Clinical Trial.
29.	Electronegative low-density lipoprotein increases the risk of ischemic lower-extremity peripheral artery disease in uremia patients on maintenance hemodialysis. Chang CT, Shen MY, Lee AS, Wang CC, Chen WY, Chang CM, Chang KC, Stancel N, Chen CH. Sci Rep. 2017 Jul 5;7(1):4654. doi: 10.1038/s41598-017-04063-3. PMID: 28680087 Free PMC article.

2016年

1.	Update on ADAMTS13 and VWF in cardiovascular and hematological disorders. Akyol O, Akyol S, Chen CH. Clin Chim Acta. 2016 Dec 1;463:109-118. doi: 10.1016/j.cca.2016.10.017. Epub 2016 Oct 14. PMID: 27746209 Review.
2.	The role of electronegative low-density lipoprotein in cardiovascular diseases and its therapeutic implications. Akyol S, Lu J, Akyol O, Akcay F, Armutcu F, Ke LY, Chen CH. Trends Cardiovasc Med. 2017 May;27(4):239-246. doi: 10.1016/j.tcm.2016.11.002. Epub 2016 Nov 19. PMID: 28040327 Review.
3.	Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis. Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH. Clin Chem. 2016 Feb;62(2):320-7. doi: 10.1373/clinchem.2015.243923. Epub 2015 Nov 25. PMID: 26607724 Review.
4.	Design of acid-responsive polymeric nanoparticles for 7,3',4'-trihydroxyisoflavone topical administration. Huang PH, Hu SC, Lee CW, Yeh AC, Tseng CH, Yen FL. Int J Nanomedicine. 2016 Apr 18;11:1615-27. doi: 10.2147/IJN.S100418. eCollection 2016. PMID: 27143883 Free PMC article.
5.	Irradiance-dependent UVB Photocarcinogenesis. Lan CE, Wu CS, Huang SM, Wu CH, Lai HC, Peng YT, Hou PS, Yang HJ, Chen GS. Sci Rep. 2016 Nov 21;6:37403. doi: 10.1038/srep37403. PMID: 27869214 Free PMC article.
6.	VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis. Lu CW, Lo YH, Chen CH, Lin CY, Tsai CH, Chen PJ, Yang YF, Wang CH, Tan CH, Hou MF, Yuan SF. Cancer Lett. 2017 Mar 1;388:130-138. doi: 10.1016/j.canlet.2016.11.033. Epub 2016 Dec 7. PMID: 27940127
7.	The Differential Levels of Inflammatory Cytokines and BDNF among Bipolar Spectrum Disorders. Wang TY, Lee SY, Chen SL, Chung YL, Li CL, Chang YH, Wang LJ, Chen PS, Chen SH, Chu CH, Huang SY, Tzeng NS, Hsieh TH, Chiu YC, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Int J Neuropsychopharmacol. 2016 Aug 12;19(8):pyw012. doi: 10.1093/ijnp/pyw012. Print 2016 Aug. PMID: 26865313 Free PMC article.
8.	Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder. Wang TY, Lee SY, Chen SL, Chang YH, Wang LJ, Chen PS, Chen SH, Chu CH, Huang SY, Tzeng NS, Li CL, Chung YL, Hsieh TH, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB. Sci Rep. 2016 Jun 7;6:27431. doi: 10.1038/srep27431. PMID: 27270858 Free PMC article. Clinical Trial.
9.	Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. Chen CH, Ke LY, Chan HC, Lee AS, Lin KD, Chu CS, Lee MY, Hsiao PJ, Hsu C, Chen CH, Shin SJ. J Lipid Res. 2016 Aug;57(8):1435-46. doi: 10.1194/jlr.M067215. Epub 2016 Jun 2. PMID: 27256691 Free PMC article.
10.	Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus. Fang TJ, Lin YZ, Liu CC, Lin CH, Li RN, Wu CC, Ou TT, Tsai WC, Yen JH. Int J Rheum Dis. 2016 Oct;19(10):968-973. doi: 10.1111/1756-185X.12783. Epub 2015 Oct 13. PMID: 26461065
11.	Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice. Wu BN, Kuo KK, Chen YH, Chang CT, Huang HT, Chai CY, Dai ZK, Chen IJ. Int J Mol Sci. 2016 Aug 17;17(8):1345. doi: 10.3390/ijms17081345. PMID: 27548140 Free PMC article.
12.	Derivation and validation of a scoring system for predicting nonalcoholic steatohepatitis in Taiwanese patients with severe obesity. Tai CM, Yu ML, Tu HP, Huang CK, Hwang JC, Chuang WL. Surg Obes Relat Dis. 2017 Apr;13(4):686-692. doi: 10.1016/j.soard.2016.11.028. Epub 2016 Dec 7. PMID: 28089433
13.	High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation. Lan CC, Huang SM, Wu CS, Wu CH, Chen GS. Transl Res. 2016 Mar;169:91-101.e1-3. doi: 10.1016/j.trsl.2015.11.002. Epub 2015 Dec 1. PMID: 26678678
14.	Interactions of a PPARGC1A Variant and a PNPLA3 Variant Affect Nonalcoholic Steatohepatitis in Severely Obese Taiwanese Patients. Tai CM, Huang CK, Tu HP, Hwang JC, Yeh ML, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. Medicine (Baltimore). 2016 Mar;95(12):e3120. doi: 10.1097/MD.0000000000003120. PMID: 27015186 Free PMC article.
15.	A cohort study on 10-year survival of sporadic medullary thyroid carcinoma with somatic RET mutation. Chuang LL, Hwang DY, Tsai KB, Chan HM, Chiang FY, Hsiao PJ. Kaohsiung J Med Sci. 2016 Nov;32(11):545-551. doi: 10.1016/j.kjms.2016.08.012. Epub 2016 Oct 14. PMID: 27847096
16.	Nonapnea Sleep Disorders and the Risk of Acute Kidney Injury: A Nationwide Population-Based Study. Lin HY, Chang KT, Chang YH, Lu T, Liang CJ, Wang DC, Tsai JH, Hsu CY, Hung CC, Kuo MC, Lin CS, Hwang SJ. Medicine (Baltimore). 2016 Mar;95(11):e3067. doi: 10.1097/MD.0000000000003067. PMID: 26986132 Free PMC article.
17.	Electronegative Low-density Lipoprotein Increases Coronary Artery Disease Risk in Uremia Patients on Maintenance Hemodialysis. Chang CT, Wang GJ, Kuo CC, Hsieh JY, Lee AS, Chang CM, Wang CC, Shen MY, Huang CC, Sawamura T, Yang CY, Stancel N, Chen CH. Medicine (Baltimore). 2016 Jan;95(2):e2265. doi: 10.1097/MD.0000000000002265. PMID: 26765403 Free PMC article.
18.	VLDL from Metabolic Syndrome Individuals Enhanced Lipid Accumulation in Atria with Association of Susceptibility to Atrial Fibrillation. Lee HC, Lin HT, Ke LY, Wei C, Hsiao YL, Chu CS, Lai WT, Shin SJ, Chen CH, Sheu SH, Wu BN. Int J Mol Sci. 2016 Jan 20;17(1):134. doi: 10.3390/ijms17010134. PMID: 26805814 Free PMC article.
19.	Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Shyu WC, Sawamura T, Chang KC, Hsu CY, Chen CH. Blood. 2016 Mar 10;127(10):1336-45. doi: 10.1182/blood-2015-05-646117. Epub 2015 Dec 17. PMID: 26679863 Free PMC article.
20.	The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism. Lee SY, Wang TY, Chen SL, Chang YH, Chen PS, Huang SY, Tzeng NS, Wang LJ, Lee IH, Chen KC, Yang YK, Yang YH, Lu RB, Chen CS. Sci Rep. 2016 Dec 1;6:37950. doi: 10.1038/srep37950. PMID: 27905499 Free PMC article. Clinical Trial.
21.	Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway. Shen WC, Liang CJ, Huang TM, Liu CW, Wang SH, Young GH, Tsai JS, Tseng YC, Peng YS, Wu VC, Chen YL. Arch Toxicol. 2016 Nov;90(11):2779-2792. doi: 10.1007/s00204-015-1652-0. Epub 2015 Dec 12. PMID: 26659566
22.	The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Hung AC, Tsai CH, Hou MF, Chang WL, Wang CH, Lee YC, Ko A, Hu SC, Chang FR, Hsieh PW, Yuan SS. Cancer Lett. 2016 Feb 28;371(2):251-61. doi: 10.1016/j.canlet.2015.11.035. Epub 2015 Dec 9. PMID: 26683774
23.	Identification of 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranoside as a Glycine N-Methyltransferase Enhancer by High-Throughput Screening of Natural Products Inhibits Hepatocellular Carcinoma. Kant R, Yen CH, Lu CK, Lin YC, Li JH, Chen YM. Int J Mol Sci. 2016 May 4;17(5):669. doi: 10.3390/ijms17050669. PMID: 27153064 Free PMC article.
24.	Time-Degenerative Factors and the Risk of Hepatocellular Carcinoma after Antiviral Therapy among Hepatitis C Virus Patients: A Model for Prioritization of Treatment. Yu ML, Huang CF, Yeh ML, Tsai PC, Huang CI, Hsieh MH, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL. Clin Cancer Res. 2017 Apr 1;23(7):1690-1697. doi: 10.1158/1078-0432.CCR-16-0921. Epub 2016 Oct 12. PMID: 27733478
25.	Age-dependent impact of new ESC-Guideline recommended door-to-balloon times on mid-term survival in acute ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Wang YC, Huang YY, Lo PH, Chang KC, Chen CH, Chen MF. Int J Cardiol. 2016 Nov 1;222:242-246. doi: 10.1016/j.ijcard.2016.07.224. Epub 2016 Jul 30. PMID: 27497102
26.	Restoration of uridine 5'-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells. Dai ZK, Kao CL, Hsieh SL, Chen IJ, Wu BN. Kaohsiung J Med Sci. 2016 Dec;32(12):607-613. doi: 10.1016/j.kjms.2016.09.008. Epub 2016 Oct 27. PMID: 27914611
27.	Modulation of potassium channel KCNQ1 transcript in right atrial appendage of patients with postoperative atrial fibrillation. Lee HC, Chiu CC, Chen CC, Huang JW, Lin HT, Hsiao YL, Sheu SH, Hsieh CC. Int J Cardiol. 2016 Nov 1;222:696-698. doi: 10.1016/j.ijcard.2016.08.020. Epub 2016 Aug 4. PMID: 27521539 No abstract available.
28.	The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder. Chang TT, Chen SL, Chang YH, Chen PS, Chu CH, Chen SH, Huang SY, Tzeng NS, Wang LJ, Wang TY, Li CL, Chung YL, Hsieh TH, Lee IH, Chen KC, Yang YK, Hong JS, Lu RB, Lee SY. Medicine (Baltimore). 2016 Jun;95(24):e3488. doi: 10.1097/MD.0000000000003488. PMID: 27310943 Free PMC article. Clinical Trial.
29.	A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages. Wu CY, Hsu WL, Wang CH, Liang JL, Tsai MH, Yen CJ, Li HW, Chiu SJ, Chang CH, Huang YB, Lin MW, Yoshioka T. PLoS One. 2016 Jul 29;11(7):e0159299. doi: 10.1371/journal.pone.0159299. eCollection 2016. PMID: 27472555 Free PMC article.
30.	Four weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir encountering dengue fever resulted in sustained virological response in an HCV patient: A case report. Huang CF, Jang TY, Lu PL, Yu ML. Medicine (Baltimore). 2016 Nov;95(47):e5304. doi: 10.1097/MD.0000000000005304. PMID: 27893666 Free PMC article.

2015年

1.	Derinat Protects Skin against Ultraviolet-B (UVB)-Induced Cellular Damage. Hsu WL, Lu JH, Noda M, Wu CY, Liu JD, Sakakibara M, Tsai MH, Yu HS, Lin MW, Huang YB, Yan SJ, Yoshioka T. Molecules. 2015 Nov 12;20(11):20297-311. doi: 10.3390/molecules201119693. PMID: 26569211 Free PMC article.
2.	Interplay between CRP, Atherogenic LDL, and LOX-1 and Its Potential Role in the Pathogenesis of Atherosclerosis. Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH. Clin Chem. 2016 Feb;62(2):320-7. doi: 10.1373/clinchem.2015.243923. Epub 2015 Nov 25. PMID: 26607724 Review.
3.	Methylation and gene expression of histone deacetylases 6 in systemic lupus erythematosus. Fang TJ, Lin YZ, Liu CC, Lin CH, Li RN, Wu CC, Ou TT, Tsai WC, Yen JH. Int J Rheum Dis. 2016 Oct;19(10):968-973. doi: 10.1111/1756-185X.12783. Epub 2015 Oct 13. PMID: 26461065
4.	High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation. Lan CC, Huang SM, Wu CS, Wu CH, Chen GS. Transl Res. 2016 Mar;169:91-101.e1-3. doi: 10.1016/j.trsl.2015.11.002. Epub 2015 Dec 1. PMID: 26678678
5.	Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation. Shen MY, Chen FY, Hsu JF, Fu RH, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Shyu WC, Sawamura T, Chang KC, Hsu CY, Chen CH. Blood. 2016 Mar 10;127(10):1336-45. doi: 10.1182/blood-2015-05-646117. Epub 2015 Dec 17. PMID: 26679863 Free PMC article.
6.	Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway. Shen WC, Liang CJ, Huang TM, Liu CW, Wang SH, Young GH, Tsai JS, Tseng YC, Peng YS, Wu VC, Chen YL. Arch Toxicol. 2016 Nov;90(11):2779-2792. doi: 10.1007/s00204-015-1652-0. Epub 2015 Dec 12. PMID: 26659566
7.	The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Hung AC, Tsai CH, Hou MF, Chang WL, Wang CH, Lee YC, Ko A, Hu SC, Chang FR, Hsieh PW, Yuan SS. Cancer Lett. 2016 Feb 28;371(2):251-61. doi: 10.1016/j.canlet.2015.11.035. Epub 2015 Dec 9. PMID: 26683774

SCI Papers