高雄醫學大學脂質科學暨老化研究中心

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION	FIELD OF STUDY	DEGREE
Kaohsiung Medical College, Kaohsiung, Taiwan	Medicine	M.D.
Chang-Gung Memorial Hospital, Taipei, Taiwan	Pathology	Resident
Texas Tech University, Lubbock, Texas	Physiology	Ph.D.
Maryland General Hospital & Univ. of Maryland	Internal Medicine	Resident
Baylor College of Medicine, Houston, Texas	Cardiology	Fellow

Positions and Honors

Professional Experience

1992-1993	Postdoctoral Associate, Section of Atherosclerosis/Medicine, Baylor College of Medicine
1993-1994	Instructor of Medicine, Baylor College of Medicine, Houston, Texas
1994-2004	Assistant Professor of Medicine, Baylor College of Medicine, Houston, Texas
2004-present	Associate Professor of Medicine, Baylor College of Medicine, Houston, Texas
2006-present	Clinical Director, Behavioral Medicine Research Center, Department of Medicine, Baylor College of Medicine
2009-present	Professor and Director, Vascular and Medicinal Research, Houston, Texas Heart Institute, Houston, Texas
2010-present	Visiting Professor and Director of L5 Research Center, China Medical University, Taichung, Taiwan
2012-2014	Visiting Professor and Director of Center for Lipid Biosciences, Kaohsiung Medical University, Taiwan
2013-present	Chairman, Research Advisory Committee, New York Heart Research Foundation, New York
2014-present	Chair Professor, Department of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

Honors and Awards

Tar box Fellowship, Texas Tech University, 1983–1986
The Methodist Hospital Foundation Award, 1993–1994
The Virginia and Ernest Cockrell Jar Award, 1994
Zeneca Pharmaceuticals Research Award, 1993–1995
AHA, Texas Affiliate, Grant-In-Aid, 1995–1997
Texas Medical Center/NASA Cooperative Research Grant, 1995–1996
AHA, National, Scientist Development Award, 1997–2000
The Atorvastatin Research Award, 1999–2000
American Diabetes Association Research Award, 2000–2003
Pfizer Independent Medical Grant, 2002–2003
American Diabetes Association Research Award, 2004–2006
Pfizer Independent Medical Grant, 2004–2005
Philip Morris Research Award, 2005–2008
AHA grant reviewer, Western Review Consortium, 2004–2008; 2011–2012
Associate Editor, Journal of Alzheimer’s Disease, 2011–2012
12^th Generation Chen Style Tai Chi Selected Disciple, 2013–life time
Editorial board, Biomedical Journal 2013–present
Outstanding Alumni Award, Kaohsiung Medical University, Taiwan, 2014--life time

Honors as a Mentor

Postdoctoral Fellow, Jeffrey P. Walterscheid, PhD, AHA Fellowship, 2006
Postdoctoral Fellow, Daming Tang, MD PhD, NIH Training Grant, 2007

Memberships in Professional Societies

American Diabetes Association
AHA, Atherosclerosis Council
International Atherosclerosis Society
American Association for the Advancement of Science
The Angiogenesis Society

publications

Publications

2016

Ke LY†, Chan HC†, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced sphingomyelinase activity in apolipoprotein B100 contributes to the atherogenicity of electronegative LDL. J Med Chem. 2016; in press.[IF=5.589; R/C=3/59=5% in CHEMISTRY, MEDICINAL]
Lee HC, Lin HT, Ke LY, Wei C, Hsiao YL, Chu CS, Lai WT, Shin SJ, Chen CH, Sheu SH, Wu BN. VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation. Int J Mol Sci. 2016; in press.
Chu CS, Ke LY, Chan HC, Chan HCB, Chen CC, Cheng KC, Lee HC, Kuo HF, Chang CT, Sheu SH, Chen CH, Lai WT. The Four Statin Benefit Groups Defined by The 2013 ACC/AHA New Cholesterol Guideline are Characterized by Increased Plasma Level of Electronegative LDL. Acta Cardiologica Sinica. 2016. in press.
Shen MY, Chen FY, Hsu JF, Chang CM, Chang CT, Liu CH, Wu JR, Lee AS, Chan HC, Sheu JR, Lin SZ, Sawamura T, Chang KC, Hsu CY*, Chen CH*. Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet activation and aggregation. Blood. 2016;127:1336-45. PMID: 26679863. [IF=10.452, R/C=2/68=2.9% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Chen CH, Ke LY, Chan HC, Lee AS, Lin KD, Chu CS, Lee MY, Hsiao PJ, Hsu C, Chen CH*, Shin SJ*. Electronegative low-density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. J Lipid Res. 2016 Jun 2. pii: jlr.M067215.[Epub ahead of print] PMID: 27256691.
Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T*, Chen CH*. Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem. 2016;62:320-7. PMID: 26607724. [IF=7.911; R/C=1/30=3.3% in MEDICAL LABORATORY TECHNOLOGY]
Chang CT, Wang GJ, Kuo CC, Hsieh JY, Lee AS, Chang CM, Wang CC, Shen MY, Huang CC, Sawamura T, Yang CY, Stancel N, Chen CH*. Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis. Medicine (Baltimore). 2016 Jan;95(2):e2265. doi:10.1097/MD.0000000000002265. PMID: 26765403. [IF=5.723; R/C=15/154=9.7% in MEDICINE, GENERAL & INTERNAL]
Jacob SP, Lakshmikanth CL, Chaithra VH, Kumari TR, Chen CH, McIntyre TM, Marathe GK. Lipopolysaccharide cross-tolerance delays platelet-activating factor-induced sudden death in Swiss Albino mice: Involvement of cyclooxygenase in cross-tolerance. PLoS One. 2016;11:e0153282. doi: 10.1371/journal.pone.0153282. eCollection 2016. PMID: 27064683. [IF=3.234; R/C=9/57=15.8% in MULTIDISCIPLINARY SCIENCES]

2015

Stancel N, Chen CC, Ke LY, Chu CS, Lu J, Sawamura T, Chen CH*. Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis. Clin Chem. 2015 Nov 25. pii: clinchem.2015.243923. [Epub ahead of print] Review. PMID: 26607724. [IF=7.911; 1/30=3.3% in MEDICAL LABORATORY TECHNOLOGY]
Huang TT, Hwang JK, Chen CH, Chu CS, Lee CW, Chen CC*. (PS)2: protein structure prediction server version 3.0. Nucleic Acids Res. 2015;43(W1):W338-42. PMID:25943546 [IF=9.112; 20/290=6.9% in NUCLEIC ACIDS RESEARCH]
Ke LY, Chan HC, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH*, Chen CH*. Enhanced sphingomyelinase activity in apolipoprotein B100 contributes to the atherogenicity of electronegative LDL. J Med Chem. 2015; in press.[IF=5.447; 3/59=5% in CHEMISTRY, MEDICINAL]
Chang CT, Kuo CC, Hsieh JY, Lee AS, Chang CM, Wang CC, Shen MY, Huang CC, Sawamura T, Yang CY, Stancel N, Wang GJ*, Chen CH*. Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis. Medicine. 2015; in press. [IF=5.723, 15/154=9.7% in MEDICINE, GENERAL & INTERNAL]
Chang KC†, Lee AS†, Chen WY, Lin YN, Hsu JF, Chan HC, Chang CM, Chang SS, Pan CC, Sawamura T, Chang CT, Su MJ*, Chen CH*. Chronic kidney disease induces electronegative low-density lipoprotein-mediated disruption of calcium homeostasis resulting in cardiac dysfunction. J Mol Cell Cardiol. 2015;84:36-44. PMID: 25871829 (Featured with webcast presentation*)[IF=5.218, CARDIAC & CARDIOVASCULAR SYSTEMS 20/125=16%]
Chen WY, Chen FY, Lee AS, Ting KH, Chang CM, Hsu JF, Lee WS, Sheu JR, Chen CH*, Shen MY*. Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro. J Nat Prod. 2015;78:225-233. PMID: 25692815. [IF=3.798; 7/59=11.9% in CHEMISTRY, MEDICINAL]
Belalcazar LM, Lang W, Haffner SM, Schwenke DC, Kriska A, Balasubramanyam A, Hoogeveen RC, Pi-Sunyer FX, Tracy RP, Ballantyne CM; Look AHEAD (Action for Health in Diabetes) Research Group including Chen CH. Improving Adiponectin Levels in IndividualsWith Diabetes and Obesity: Insights From Look AHEAD. Diabetes Care. 2015 May 13. pii: dc142775. [Epub ahead of print] PMID: 25972574. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Look AHEAD Research Group including Chen CH. Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: the Look AHEAD randomised controlled trial. Diabetologia. 2015 May 14. [Epub ahead of print] PMID: 25972230. [IF=6.671; 13/128=10.1% in ENDOCRINOLOGY & METABOLISM]
Unick JL, Neiberg RH, Hogan PE, Cheskin LJ, Dutton GR, Jeffery R, Nelson JA, Pi-Sunyer X, West DS, Wing RR; Look AHEAD Research Group including Chen CH. Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later. Obesity. 2015;23:1353-6. PMID: 26110890. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Raynor HA, Anderson AM, Miller GD, Reeves R, Delahanty LM, Vitolins MZ, Harper P, Mobley C, Konersman K, Mayer-Davis E; the Look AHEAD Research Group; the Look AHEAD Research Group including Chen CH. Partial meal replacement plan and quality of the diet at 1 year: Action for Health in Diabetes (Look AHEAD) Trial. J Acad Nutr Diet. 2015;115:731-42. PMID: 25573655. [IF=3.467; 16/77=20.1% in NUTRITION & DIETETICS]
Pownall HJ, Bray GA, Wagenknecht LE, Walkup MP, Heshka S, Hubbard VS, Hill J, Kahn SE, Nathan DM, Schwartz AV, Johnson KC; Look AHEAD Research Group including Chen CH. Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study. Obesity (Silver Spring). 2015;23:565-72. PMID: 25707379. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Espeland MA, Probstfield J, Hire D, Redmon JB, Evans GW, Coday M, Lewis CE, Johnson KC, Wilmoth S, Bahnson J, Dulin MF, Green JB, Knowler WC, Kitabchi A, Murillo AL, Osei K, Rehman SU, Cushman WC; the Look AHEAD Research Group including Chen CH; the ACCORD Study Group. Systolic blood pressure control among individuals with type 2 diabetes: A comparative effectiveness analysis of three interventions. Am J Hypertens. 2015 Feb 9. pii: hpu292. [Epub ahead of print] PMID: 25666468. [IF=2.852; 25/60=41.7% in PERIPHERAL VASCULAR DISEASE]

2014

Lee AS, Chen WY, Chan HC, Hsu JF, Shen MY, Chang CM, Bair H, Su MJ, Chang KC, Chen CH*. Gender disparity in LDL-induced cardiovascular damage and the protective role of estrogens against electronegative LDL. Cardiovasc Diabetol. 2014;13:64. PMID: 24666525. [IF=4.015; 29/123=23.6% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Hsu JF†, Chou TC†, Lu J, Chen SH, Chen FY, Chen CC, Chen JL, Elayda M, Ballantyne CM, Shayani S*, Chen CH*. Low-density lipoprotein electronegativity is a novel cardiometabolic risk factor. PLOS One. 2014;9(9):e107340. PMID: 25203525. [IF=3.234; 9/57=15.8% in MULTIDISCIPLINARY SCIENCES]
Ke LY†, Stancel N†, Bair H, Chen CH*. The underlying chemistry of electronegative LDL’s atherogenicity. Curr Atheroscler Rep. 2014;16:428. doi: 10.1007/s11883-014-0428-y. PMID:24890631 [IF=3.417; 18/60=30.0% in PERIPHERAL VASCULAR DISEASE]
Yang TC, Chen YJ, Chang SF, Chen CH, Chang PY*, Lu SC. Malondialdehyde mediates oxidized LDL-induced coronary toxicity through the Akt-FGF2 pathway via DNA methylation. J Biomed Sci. 2014;21:11. PMID: 24490960. [IF=2.763; 50/123=40.7% in MEDICINE, RESEARCH & EXPERIMENTAL]
Tsao CR, Liao MF, Wang MH, Cheng CM, Chen CH*. Mesenchymal stem cell derived exosomes: A new hope for the treatment of cardiovascular disease? Acta Cardiol Sin. 2014;30:395-400. [IF=0.331; 121/123=98.4% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Espeland MA, et al., Look AHEAD Research Group including Chen CH. Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes. Diabetes Care. 2014;37:2548-2556. PMID: 25147253. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Knowler WC, Bahnson JL, Bantle JP, Lewis CE; Look AHEAD Research Group including Chen CH. Diabetic kidneys do deserve a lifestyle change. Lancet Diabetes Endocrinol. 2014 Oct;2(10):776. doi: 10.1016/S2213-8587(14)70204-9. PMID: 25282082. [IF=9.185; 6/128=4.5% in ENDOCRINOLOGY & METABOLISM]
Unick JL, Gaussoin S, Bahnson J, Crow R, Curtis J, Killean T, Regensteiner JG, Stewart KJ, Wing RR, Jakicic JM; The Look AHEAD Research Group including Chen CH. Validity of Ratings of Perceived Exertion in Patients with Type 2 Diabetes. J Nov Physiother Phys Rehabil. 2014 Jul 7;1(1). pii: 102. PMID: 25485308.
Knowler WC, Bahnson JL, Bantle JP, Lewis CE; Look AHEAD Research Group including Chen CH. Diabetic kidneys do deserve a lifestyle change. Lancet Diabetes Endocrinol. 2014;2:776. PMID: 25282082. [IF=9.185; 6/128=4.5% in ENDOCRINOLOGY & METABOLISM]
Belalcazar LM, et al., Look AHEAD Research Group including Chen CH. Fiber Intake and Plasminogen Activator Inhibitor-1 in Type 2 Diabetes: Look AHEAD (Action for Health in Diabetes) Trial Findings at Baseline and Year 1. J Acad Nutr Diet. 2014 Aug 14. pii: S2212-2672(14)01046-6. doi: 10.1016/j.jand.2014.06.357. [Epub ahead of print] PMID: 25131348. [IF=3.467; 16/77=20.1% in NUTRITION & DIETETICS]
Knowler WC, Bahnson JL, Bantle JP, Lewis CE; Look AHEAD Research Group including Chen CH. The Look AHEAD study: a missed opportunity - Authors' Reply. Lancet Diabetes Endocrinol. 2014;2:776. PMID: 25282083. [IF=9.185; 6/128=4.5% in ENDOCRINOLOGY & METABOLISM]
The Look AHEAD Research Group including Chen CH. Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial. Lancet Diabetes Endocrinol. 2014 Aug 8. pii: S2213-8587(14)70156-1. doi: 10.1016/S2213-8587(14)70156-1. [Epub ahead of print] PMID: 25127483. [IF=9.185; 6/128=4.5% in ENDOCRINOLOGY & METABOLISM]
Lipkin EW, Kahn SE, et al; and the Look AHEAD Research Group including Chen CH. The Look AHEAD Trial: Bone Loss at Four-Year Follow-Up in Type 2 Diabetes. Diabetes Care. 2014 Jul 21. pii: DC_140762. [Epub ahead of print]. PMID: 25048381. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Yoneyama S et al., the Look AHEAD Research Group including Chen CH. Gene-centric meta-analyses for central adiposity traits in up to 57,412 individuals of European descent confirm known loci and reveal several novel associations. Hum Mol Genet. 2014;23:2498-2510. PMID: 24345515. [IF=6.393; 17/167=10.2% in GENETICS & HEREDITY]
Rejeski WJ, et al., the Look AHEAD Research Group including Chen CH. Aging and Physical Function in Type 2 Diabetes: 8 Years of an Intensive Lifestyle Intervention. J Gerontol A Biol Sci Med Sci. 2014 Jul 1. pii: glu083. [Epub ahead of print] PMID: 24986062. [IF=5.416; 3/50=6% in GERIATRICS & GERONTOLOGY]
Look AHEAD Research Group including Chen CH. Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: The Look AHEAD Trial. Diabetes Care. 2014;37:1544-53. PMID: 24855155. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Espeland MA, Lewis CE, Bahnson J, Knowler WC, Regensteiner JG, Gaussoin SA, Beavers D, Johnson KC; Look AHEAD Research Group including Chen CH. Impact of weight loss on ankle-brachial index and interartery blood pressures. Obesity. 2014;22:1032-41. PMID: 24174392. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Fitzpatrick SL, Jeffery R, Johnson KC, Roche CC, Van Dorsten B, Gee M, Johnson RA, Charleston J, Dotson K, Walkup MP, Hill-Briggs F, Brancati FL; The Look AHEAD Research Group including Chen CH. Baseline predictors of missed visits in the look AHEAD study. Obesity. 2014;22:131-40. PMID: 23996977. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Eight-year weight losses with an intensive lifestyle intervention: The look AHEAD study.Look AHEAD Research Group including Chen CH. Obesity. 2014;22:5-13. PMID: 24307184. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Wing RR, Leahey T, Jeffery R, Johnson KC, Hill JO, Coday M, Espeland MA; The Look AHEAD Research Group including Chen CH. Do weight loss and adherence cluster within behavioral treatment groups? Obesity. 2014;22:638-44. PMID: 23804576. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Unick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G, Jeffery R, Kitabchi AE, Nelson JA, Pi-Sunyer FX, West DS, Wing RR; The Look AHEAD Research Group including Chen CH. Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. Obesity. 2014;22:1608-1616. PMID: 24771618. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Espeland MA, Rapp SR, Kritchevsky SB et al., the Look AHEAD Research Group including Chen CH. Long-term impact of behavioral weight loss intervention on cognitive function. J Gerontol A Biol Sci Med Sci. 2014 Mar 11. [Epub ahead of print]. PMID: 24619151. [IF=5.416; 3/50=6% in GERIATRICS & GERONTOLOGY]
Breyer BN, Phelan S, Hogan PE, Rosen RC, Kitabchi AE, Wing RR, Brown JS; Look Ahead Research Group including Chen CH. Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: Results from the Look AHEAD trial. J Urol. 2014 Feb 14. pii: S0022-5347(14)00288-2. [Epub ahead of print] PMID: 24533998. [IF=4.360; 10/78=12.8% in UROLOGY & NEPHROLOGY]

2013

Chan HC†, Ke LY†, Chu CS, Lee AS, Shen MY, Cruz MA, Hsu JF, Cheng KH, Chan HC, Lu J, Lai WT, Sawamura T, Sheu SH, Yen JH*, Chen CH*. Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation. Blood. 2013;122:3632-3641. PMID: 24030386 (Featured with editorial comment*). [IF=10.452, 2/68=2.9% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Hsieh JY†, Chang CT†, Huang MT, Chang CM, Chen CY, Shen MY, Liao HY, Wang GJ,Chen CH*, Chen CJ*, Yang CY*. Biochemical and functional characterization of charge-defined subfractions of high-density lipoprotein from normal adults.Anal Chem.2013;85:11440-11448. PMID: 24171625. [IF=5.636, 4/74=5.4% in CHEMISTRY, ANALYTICAL]
Chang PY, Chen YJ, Chang FH, Lu J, Huang WH, Yang TC, Lee YT, Chang SF, Lu SC, Chen CH*. Aspirin protects human coronary artery endothelial cells against atherogenic electronegative LDL via an epigenetic mechanism: A novel cytoprotective role of aspirin in acute myocardial infarction.Cardiovasc Res. 2013;99:137-145. PMID: 23519265. [IF=5.940, 11/123=8.9% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Chu CS, Wang YC, Lu LS, Walton B, Yilmaz HR, Huang RY, Sawamura T, Dixon RAF, Lai WT, Chen CH*, Lu J*. Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor. PLOS One. 2013;8(8):e70533. PMID: 23950953. [IF=3.234; 9/57=15.8% in MULTIDISCIPLINARY SCIENCES]
Chang CT, Liao HY, Chang CM, Chen CY, Chen CH, Yang CY, Tsai FJ, Chen CJ. Oxidized ApoC1 on MALDI-TOF and glycated-ApoA1 band on gradient gel as potential diagnostic tools for atherosclerotic vascular disease. Clin Chim Acta. 2013;420:69-75. PMID: 23078847. [IF=2.824; 5/30=16.7% in MEDICAL LABORATORY TECHNOLOGY]
The Look AHEAD Research Groupincluding Chen CH, Wing RR et al. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369:145-154. PMID: 23796131. [IF=55.873; 1/154=0.6% in MEDICINE, GENERAL & INTERNAL]
Wing RR, Reboussin D, Lewis CE; Look AHEAD Research Groupincluding Chen CH. Intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369:2358-9. PMID: 24328474. [IF=55.873; 1/154=0.6% in MEDICINE, GENERAL & INTERNAL]
McCaffery JM, Papandonatos GD, Huggins GS, Peter I, Erar B, Kahn SE, Knowler WC, Lipkin EW, Kitabchi AE, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group including Chen CH. Human cardiovascular disease IBC chip-wide association with weight loss and weight regain in the look AHEAD trial. Hum Hered. 2013;75:160-74. PMID: 24081232. [IF=1.474; 127/169=75.1% in GENETICS & HEREDITY]
Unick JL, Beavers D, Bond DS, Clark JM, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wagenknecht LE, Wing RR; Look AHEAD Research Group including Chen CH. The long-term effectiveness of a lifestyle intervention in severely obese individuals. Am J Med. 2013;126:236-242, 242.e1-2. PMID: 23410564. [IF=5.003; 18/154=11.7% in MEDICINE, GENERAL & INTERNAL]
Rubin RR, Peyrot M, Gaussoin SA, Espeland MA, Williamson D, Faulconbridge LF, Wadden TA, Ewing L, Safford M, Evans-Hudnall G, Wing RR, Knowler WC; Look AHEAD Research Groupincluding Chen CH. Four-year analysis of cardiovascular disease risk factors, depression symptoms, and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetes Care. 2013;36:1088-94. PMID: 23359362. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Jakicic JM, Egan CM, Fabricatore AN, Gaussoin SA, Glasser SP, Hesson LA, Knowler WC, Lang W, Regensteiner JG, Ribisl PM, Ryan DH; Look AHEAD Research Group including Chen CH. Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: the Look AHEAD Trial. Diabetes Care. 2013;36:1297-1303. PMID: 23223405. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Belalcazar LM, Haffner SM, Lang W, Hoogeveen RC, Rushing J, Schwenke DC, Tracy RP, Pi-Sunyer FX, Kriska AM, Ballantyne CM;Look AHEAD Research Groupincluding Chen CH. Lifestyle intervention and/or statins for the reduction of C-reactive protein in type 2 diabetes: from the look AHEAD study.Obesity. 2013;21:944-50. PMID: 23512860. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]

2012

Chen CH*, Lu J, Chen SH, Huang RY, Yilmaz HR, Dong J, Elayda MA, Dixon RAF, Yang CY. Effects of electronegative VLDL on endothelium damage in metabolic syndrome. Diabetes Care. 2012;35:648-653. PMID: 22279032. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Tsai MH, Chang CL, Yu YS, Lin TY, Chong CP, Yang JY, Lin YS, Su MY, Shu TY, Lu J, Chen CH*, Liu MY*. Chemical analysis of C-reactive protein synthesized by human aortic endothelial cells under oxidative stress. Anal Chem. 2012;84:9646-9654. PMID: 23046186. [IF=5.636, 4/74=5.4% in CHEMISTRY, ANALYTICAL]
Lee AS, Wang GJ, Chan HC, Chen FY, Chang CM, Yang CY, Lee YT, Chang KC, Chen CH*. Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell–released chemokines. Apoptosis. 2012;17:1009-18. PMID: 22562555. [IF=3.685; 87/290=30% in BIOCHEMISTRY & MOLECULAR BIOLOGY]
Chen CY, Hsu HC, Lee AS, Tang D, Chow LP, Yang CY, Chen H, Lee YT, Chen CH*. The most negatively charged low-density lipoprotein L5 induces stress pathways in vascular endothelial cells. J Vasc Res. 2012;49:329-341. PMID: 22627396. [IF=2.901; 28/83=33.7% in PHYSIOLOGY]
Wang GJ, Chang CT, Yang CY. Chen CH* Negatively charged L5 as a naturally occurring atherogenic low-density lipoprotein. BioMedicine. 2012;2:147-154.
Chang PY, Lee CM, Hsu HC, Lin HJ, Chien KL, Chen MF, Chen CH, Lee YT, Yang CY. Identification of the HDL-ApoCIII to VLDL-ApoCIII ratio as a predictor of coronary artery disease in the general population: The Chin-Shan Community Cardiovascular Cohort (CCCC) study in Taiwan. Lipids Health Dis. 2012;11:162. PMID: 23173569. [IF=2.219, 44/77=57.1% in NUTRITION & DIETETICS]
Wang YC, Lo PH, Chang SS, Lin JJ, Wang HJ, Chang CP, Hsieh LC, Chen YP, Chen WK, Chen CH, Chang KC, Hung JS. Reduced door-to-balloon times in acute ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.Int J Clin Pract. 2012;66:69-76. PMID: 22171906. [IF=2.566, 35/157=22.3% in MEDICINE, GENERAL & INTERNAL]
Chang KC, Huang CL, Liang HY, Chang SS, Wang YC, Liang WM, Lane HY, Chen CH, Huang, SK. Gender-specific differences in susceptibility to low-dose methadone-associated QTc prolongation in patients with heroin dependence.J Cardiovasc Electrophysiol. 2012;23:527-33. PMID: 22136144 [IF=3.156; 43/123=35% in CARDIAC & CARDIOVASCULAR SYSTEMS]
Rejeski WJ, Ip EH, Bertoni AG, Bray GA, Evans G, Gregg EW, Zhang Q; Look AHEAD Research Group including Chen CH. Lifestyle change and mobility in obese adults with type 2 diabetes. N Engl J Med. 2012;366:1209-1217. PMID: 22455415. [IF=55.873; 1/154=0.6% in MEDICINE, GENERAL & INTERNAL]
Gregg EW, Chen H, Wagenknecht LE, Clark JM, Delahanty LM, Bantle J, Pownall HJ, Johnson KC, Safford MM, Kitabchi AE, Pi-Sunyer FX, Wing RR, Nertoni AG; for the Look AHEAD Research Group including Chen CH. Association of an intensive lifestyle intervention with remission of Type 2 diabetes. JAMA. 2012;308:2489-2496. PMID: 23288372. [IF=35.289; 3/154=1.9% in MEDICINE, GENERAL & INTERNAL]
Belalcazar LM, Lang W, Haffner SM, Hoogeveen RC, Pi-Sunyer FX, Schwenke DC, Balasubramanyam A, Tracy RP, Kriska AP, Ballantyne CM; Look AHEAD Research Group including Chen CH. Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: the Look AHEAD Study. J Lipid Res. 2012;53:2726-2733. PMID: 22956782. [IF=4.421; 65/290=22.4% in BIOCHEMISTRY & MOLECULAR BIOLOGY]
Ribisl PM, Gaussoin SA, Lang W, Bahnson J, Connelly SA, Horton ES, Jakicic JM, Killean T, Kitzman DW, Knowler WC, Stewart KJ; Look AHEAD Research Group including Chen CH. Lifestyle intervention improves heart rate recovery from exercise in adults with type 2 diabetes: results from the Look AHEAD study. J Obes. 2012;2012:309196. PMID: 23227314. [IF=5.004; 8/77=10.4% in NUTRITION & DIETETICS]
Saxena R et al; Look AHEAD Research Group including Chen CH. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet. 2012;90:410-25. PMID: 22325160. [IF=10.931; 6/167=3.6% in GENETICS & HEREDITY]
Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, DiLillo V, Gorin AA, West DS, Brown JS; Look AHEAD Research Group including Chen CH. Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial. J Urol. 2012;187:939-44. PMID: 22264468. [IF=4.360; 10/78=12.8% in UROLOGY & NEPHROLOGY]
Wang IK, Lai HC, Yu CJ, Liang CC, Chang CT, Kuo HL, Yang YF, Lin CC, Lin HH, Liu YL, Chang YC, Wu YY, Chen CH, Li CY, Chuang FR, Huang CC, Lin CH, Lin HC. Real-time PCR Analysis of intestinal microbiota in peritoneal dialysis patients. Appl Environ Microb. 2012;78:1107-1112. PMID: 22179250. [IF=3.688; 34/163=20.9% in BIOTECHNOLOGY & APPLIED MICROBIOLOGY]
McCaffery JM, Papandonatos GD, Peter I, Huggins GS, Raynor HA, Delahanty LM, Cheskin LJ, Balasubramanyam A, Wagenknecht LE, Wing RR; Genetic Subgroup of Look AHEAD; Look AHEAD Research Group including Chen CH. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. Am J Clin Nutr. 2012;95:1477-1486. PMID: 22513296. [IF=6.770; 3/77=3.9% in NUTRITION & DIETETICS]
Peter I, McCaffery JM, Kelley-Hedgepeth A, Hakonarson H, Reis S, Wagenknecht LE, Kopin AS, Huggins GS; Look AHEAD Study including Chen CH. Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity. 2012;20:1675-1682. PMID: 22307069. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Faulconbridge LF, Wadden TA, Rubin RR, Wing RR, Walkup MP, Fabricatore AN, Coday M, Van Dorsten B, Mount DL, Ewing LJ; Look AHEAD Research Group including Chen CH. One-year changes in symptoms of depression and weight in overweight/obese individuals with type 2 diabetes in the Look AHEAD study. Obesity. 2012;20:783-793. PMID: 22016099. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Mount DL, Davis C, Kennedy B, Raatz S, Dotson K, Gary-Webb TL, Thomas S, Johnson KC, Espeland MA; Look AHEAD Research Groupincluding Chen CH. Factors influencing enrollment of African Americans in the Look AHEAD trial. Clin Trials. 2012;9:80-9. PMID: 22064686. [IF=1.925; 77/123=62.6% in MEDICINE, RESEARCH & EXPERIMENTAL]
Schwartz AV, Johnson KC, Kahn SE, Shepherd JA, Nevitt MC, Peter AL, Walkup MP, Hodges A, Williams CC, Bray GA, Look AHEAD Research Group including Chen CH. Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial. J Bone Miner Res.2012:27:619-627. PMID: 22354851.
Brancati FL, Evans M, Furberg CD, Geller N, Haffner S, Kahn SE, Kaufmann PG, Lewis CE, Nathan DM, Pitt B, Safford MM;Look AHEAD Study Groupincluding Chen CH. Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Clin Trials. 2012;9:113-124. PMID: 22334468. [IF=1.925; 77/123=62.6% in MEDICINE, RESEARCH & EXPERIMENTAL]
Neiberg RH, Wing RR, Bray GA, Reboussin DM, Rickman AD, Johnson KC, Kitabchi AE, Faulconbridge LF, Kitzman DW, Espeland MA;Look AHEAD Research Group including Chen CH. Patterns of weight change associated with long-term weight change and cardiovascular disease risk factors in the Look AHEAD Study.Obesity. 2012;20:2048-56. PMID: 22327053. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]

2011

Ke LY, Engler DA, Lu J, Matsunami RK, Chan HC, Wang GJ, Yang CY, Chang JG, Chen CH*. Chemical composition–oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein.Pure Appl Chem. 2011;83:1731-1740. PMID: 24198440. [IF=2.492; 52/157=33.1% in CHEMISTRY, MULTIDISCIPLINARY]
Wong SL, Chang HS, Wang GJ, Chiang MY, Huang HY, Chen CH, Tsai SC, Lin CH, Chen LS. 2011, Secondary metabolites from the root of Neolitsea daibuensis and their antiinflammatory activity. J Nat Prod. 2011;74:2489-96. PMID: 22148193. [IF=3.798; 7/59=11.9% in CHEMISTRY, MEDICINAL]
Chen HH, Chen CY, Chow LP, Chen CH, Lee YT, Smith CV, Yang CY. Iron-catalyzed oxidation of Trp residues in low-density lipoprotein. Biol Chem. 2011;392:859-867. PMID: 21848505. [IF=3.268; 106/290=36.6% in BIOCHEMISTRY & MOLECULAR BIOLOGY]
Huang YT, Chang HS, Wang GJ, Cheng MJ, Chen CH, Yang YJ, Chen IS. Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii. J Nat Prod. 2011;74:1875-1880. PMID: 21846089. [IF=3.798; 7/59=11.9% in CHEMISTRY, MEDICINAL]
Unick JL, Beavers D, Jakicic JM, Kitabchi AE, Knowler WC, Wadden TA, Wing RR; Look AHEAD Research Group including Chen CH. Effectiveness of lifestyle interventions for individuals with severe obesity and type 2 diabetes: results from the Look AHEAD trial. Diabetes Care. 2011;34:2152-2157. PMID: 21836103. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Gary-Webb TL, Baptiste-Roberts K, Pham L, Wesche-Thobaben J, Patricio J, Pi-Sunyer FX, Brown AF, Jones-Corneille L, Brancati FL; Look AHEAD Research Group. Neighborhood socioeconomic status, depression, and health status in the Look AHEAD (Action for Health in Diabetes) study including Chen CH). BMC Public Health. 2011;11:349. PMID: 22182286. [IF=2.264; 53/165=32.1% in PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH]
Foy CG, Lewis CE, Hairston KG, Miller GD, Lang W, Jakicic JM, Rejeski WJ, Ribisl PM, Walkup MP, Wagenknecht LE; Look AHEAD Research Group including Chen CH. Intensive lifestyle intervention improves physical function among obese adults with knee pain: findings from the Look AHEAD trial. Obesity. 2011;19:83-93. PMID: 20559303. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Wadden TA, Neiberg RH, Wing RR, Clark JM, Delahanty LM, Hill JO, Krakoff J, Otto A, Ryan DH, Vitolins MZ; Look AHEAD Research Group including Chen CH. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity. 2011;19:1987-98. PMID: 21779086. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Smart-Halajko MC, Kelley-Hedgepeth A, Montefusco MC, Cooper JA, Kopin A, McCaffrey JM, Balasubramanyam A, Pownall HJ, Nathan DM, Peter I, Talmud PJ, Huggins GS; Look AHEAD Studyincluding Chen CH. ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial. BMC Med Genet. 2011;12:89. doi: 10.1186/1471-2350-12-89. PMID: 21714923. [IF=2.083; 110/167=65.9% in GENETICS & HEREDITY]
Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, Hill JO, Brancati FL, Peters A, Wagenknecht L; Look AHEAD Research Group including Chen CH. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.Diabetes Care. 2011;34:1481-6. PMID: 21593294. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]

2010

Chang PY, Lu SC, Chen CH*. S-Adenosylhomocysteine: A better marker of the development of Alzheimer's disease than homocysteine? J Alzheimers Dis. 2010;21:65-66. PMID: 20413857. [IF=4.151; 58/252=23% in NEUROSCIENCES]
Chang PY, Lu SC, Lee YT, Chen CH*. Comment on: Song et al. (2009) Effect of homocysteine-lowering treatment with folic acid and B vitamins on risk of type 2 diabetes in women: A randomized, controlled trial. Diabetes 58:1921-1928. Diabetes. 2010;59(3):e1. PMID: 20190132. [IF=8.095; 8/128=6.2% in ENDOCRINOLOGY & METABOLISM]
Yang SS, Wang GJ, Cheng KF, Chen CH, Ju YM, Tsau YJ, Lee TH. Bioactive γ-lactones from the fermented broth of Neosartorya sp. Planta Med. 2010;76:1701-1705. PMID:20446242.
Wang GJ, Lin YL, Chen CH,Wu XC, Liao JF, Ren J. Cellular calcium regulatory machinery of vasorelaxation elicited by petasin. Clin Exp Pharmacol Physiol. 2010;37:309–315.
Look AHEAD Research Group (including Chen CH), Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170:1566-75. PMID: 20876408. [IF=17.333; 6/154=3.9% in MEDICINE, GENERAL & INTERNAL]
Belalcazar LM, Reboussin DM, Haffner SM, Hoogeveen RC, Kriska AM, Schwenke DC, Tracy RP, Pi-Sunyer FX, Ballantyne CM;Look AHEAD Research Group including Chen CH. A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change: from the Look AHEAD (Action for Health in Diabetes) study.Diabetes Care. 2010;33:2297-303. PMID: 20682679. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Gary-Webb TL, Baptiste-Roberts K, Pham L, Wesche-Thobaben J, Patricio J, Pi-Sunyer FX, Brown AF, Jones L, Brancati FL; Look AHEAD Research Group including Chen CH. Neighborhood and weight-related health behaviors in the Look AHEAD (Action for Health in Diabetes) study. BMC Public Health. 2010;10:312. PMID: 20525373. [IF=2.264; 53/165=32.1% in PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH]
Rubin RR, Gaussoin SA, Peyrot M, DiLillo V, Miller K, Wadden TA, West DS, Wing RR, Knowler WC; Look AHEAD Research Groupincluding Chen CH. Cardiovascular disease risk factors, depression symptoms and antidepressant medicine use in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss in diabetes. Diabetologia. 2010;53:1581-9. PMID: 20422396. [IF=6.671; 13/128=10.1% in ENDOCRINOLOGY & METABOLISM]
Redmon JB, Bertoni AG, Connelly S, Feeney PA, Glasser SP, Glick H, Greenway F, Hesson LA, Lawlor MS, Montez M, Montgomery B;Look AHEAD Research Group including Chen CH. Effect of the look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes.Diabetes Care. 2010;33:1153-8. PMID: 20332353. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Curtis JM, Horton ES, Bahnson J, Gregg EW, Jakicic JM, Regensteiner JG, Ribisl PM, Soberman JE, Stewart KJ, Espeland MA; Look AHEAD Research Group including Chen CH. Prevalence and predictors of abnormal cardiovascular responses to exercise testing among individuals with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) study. Diabetes Care. 2010;33:901-7. PMID: 20056948. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Belalcazar LM, Reboussin DM, Haffner SM, Reeves RS, Schwenke DC, Hoogeveen RC, Pi-Sunyer FX, Ballantyne CM;Look AHEAD Research Group including Chen CH. Marine omega-3 fatty acid intake: associations with cardiometabolic risk and response to weight loss intervention in the Look AHEAD (Action for Health in Diabetes) study.Diabetes Care. 2010;33:197-9. PMID: 19841042. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]

2009

Lu J, Yang JH, Burns AR, Chen HH, Tang D, Walterscheid JP, Suzuki S, Yang CY, Sawamura T, Chen CH*. Mediation of electronegative LDL signaling by LOX-1: A possible mechanism of endothelial apoptosis. Circ Res. 2009;104:619-627. PMID: 19150883. [IF=11.019; 1/68=1.5% in HEMATOLOGY]
Chen CH*, Dixon RAF, Ke LY, Willerson JT. Vascular progenitor cells in diabetes mellitus: Roles of Wnt signaling and negatively charged LDL. Circ Res. 2009;104:1038-1040. PMID:19423862. [IF=11.019; 1/68=1.5% in HEMATOLOGY]
Mount DL, Feeney P, Fabricatore AN, Coday M, Bahnson J, Byington R, Phelan S, Wilmoth S, Knowler WC, Hramiak I, Osei K, Sweeney ME, Espeland MA; Look AHEAD and ACCORD Research Groupsincluding Chen CH. Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials. Clin Trials. 2009;6:416-29. PMID: 19737845. [IF=1.925; 77/123=62.6% in MEDICINE, RESEARCH & EXPERIMENTAL]
Vitolins MZ, Anderson AM, Delahanty L, Raynor H, Miller GD, Mobley C, Reeves R, Yamamoto M, Champagne C, Wing RR, Mayer-Davis E; Look AHEAD Research Group including Chen CH. Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intake. J Am Diet Assoc. 2009;109:1367-75. PMID: 19631042. [IF=8.095; 8/128=6.2% in ENDOCRINOLOGY & METABOLISM]
Espeland MA, Bray GA, Neiberg R, Rejeski WJ, Knowler WC, Lang W, Cheskin LJ, Williamson D, Lewis CB, Wing R; Look Ahead Study Group including Chen CH. Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research group. Ann Epidemiol. 2009;19:701-10. PMID: 19628410. [IF=2.000; 64/165=38.8% in PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH]
Phelan S, Kanaya AM, Subak LL, Hogan PE, Espeland MA, Wing RR, Burgio KL, Dilillo V, Gorin AA, West DS, Brown JS; Action for Health in Diabetes Look AHEAD Research Groupincluding Chen CH. Prevalence and risk factors for urinary incontinence in overweight and obese diabetic women: action for health in diabetes (look ahead) study. Diabetes Care. 2009;32:1391-7. PMID: 19487639. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Kramer H, Reboussin D, Bertoni AG, Marcovina S, Lipkin E, Greenway FL 3rd, Brancati FL; Look Ahead Research Group including Chen CH. Obesity and albuminuria among adults with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) Study. Diabetes Care. 2009;32:851-3. PMID: 19196893. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]
Wadden TA, West DS, Neiberg RH, Wing RR, Ryan DH, Johnson KC, Foreyt JP, Hill JO, Trence DL, Vitolins MZ; Look AHEAD Research Group including Chen CH. One-year weight losses in the Look AHEAD study: factors associated with success. Obesity. 2009;17:713-22. PMID: 19180071. [IF=3.734; 7/59=19.5% in NUTRITION & DIETETICS]
Williamson DA, Rejeski J, Lang W, Van Dorsten B, Fabricatore AN, Toledo K;Look AHEAD Research Group including Chen CH. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Arch Intern Med. 2009;169:163-71. PMID: 19171813. [IF=17.333; 6/154=3.9% in MEDICINE, GENERAL & INTERNAL]

2008

Lu J, Jiang W, Yang JH, Chang PY, Walterscheid JP, Chen HH, Marcelli M, Tang D, Lee YT, Liao WSL, Yang CY, Chen CH*. Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting FGF2 autoregulation. Diabetes. 2008;57:158-166. PMID: 17959932. [IF=8.095; 8/128=6.2% in ENDOCRINOLOGY & METABOLISM]
Tang D, Lu J, Walterscheid JP, Chen HH, Engler DA, Sawamura T, Chang PY, Safi HJ, Yang CY, Chen CH*. Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res. 2008;49:33-47. PMID: 17909223. [IF=4.421; 65/290=22.4% in BIOCHEMISTRY & MOLECULAR BIOLOGY]
Chang PY, Lu SC, Lee CM, Chen YJ, Dugan TA, Huang WH Chang SF, Liao WS,Chen CH, Lee YT. Homocysteine inhibits arterial endothelial cell growth through transcriptional downregulation of fibroblast growth factor-2 involving G protein and DNA methylation.Circ Res. 2008;102:933-941. PMID: 18309099. [IF=11.019; 1/68=1.5% in HEMATOLOGY]
Heshka S, Ruggiero A, Bray GA, Foreyt J, Kahn SE, Lewis CE, Saad M, Schwartz AV; Look AHEAD Research Group (including Chen CH). Altered body composition in type 2 diabetes mellitus. Int J Obes (Lond). 2008;32:780-7. PMID: 18227843. [IF=5.004; 8/77=10.4% in NUTRITION & DIETETICS]

2007

Yang CH, Chen HH, Huang MT, Raya JL, Yang JH, Chen CH, Gaubatz JW, Pownall HJ, Taylor AA, Ballantyne CM, Jenniskens FA, Smith CV. Pro-apoptotic low-density lipoprotein subfractions in type II diabetes atherosclerosis.Atherosclerosis. 2007;193:283-91. [IF=3.994; 11/60=18.3% in PERIPHERAL VASCULAR DISEASE]
Cheng J, CuiR, Chen CH, Du J. Oxidized low-density lipoprotein stimulates p53-dependent activation of proapoptotic Bax leading to apoptosis of differentiated endothelial progenitor cells. Endocrinology. 2007;485:2085-2094. PMID: 17289842. [IF=4.503; 28/128=21.9% in ENDOCRINOLOGY & METABOLISM]
Look AHEAD Research Group (including Chen CH), Pi-Sunyer X et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one year results of the look AHEAD trial. Diabetes Care. 2007;30:1374-83. PMID: 17363746. [IF=8.420; 7/128=5.5% in ENDOCRINOLOGY & METABOLISM]

2006

Chen CH*, Walterscheid JP. Plaque angiogenesis versus compensatory arteriogenesis in atherosclerosis. Circ Res. 2006;99:787-789. PMID: 17038645. [IF=11.019; 1/68=1.5% in HEMATOLOGY]
Espeland MA, Dotson K, Jaramillo SA, Kahn SE, Harrison B, Montez M, Foreyt JP, Montgomery B, Knowler WC; Look AHEAD Research Group (including Chen CH). Consent for genetics studies among clinical trial participants: findings from Action for Health in Diabetes (Look AHEAD). Clin Trials. 2006;3:443-56. PMID: 17060218. [IF=1.925; 77/123=62.6% in MEDICINE, RESEARCH & EXPERIMENTAL]

2004

Chen CH*, Poucher SM,Lu J, Henry PD. Fibroblast growth factor 2: From laboratory evidence to clinical application. Curr Vasc Pharmacol. 2004;2:33-43 (figure used for cover page). PMID:15320831 (Featured with front cover figure*). [IF=2.966; 84/255=32.9% in PHARMACOLOGY & PHARMACY]
Chen CH*. Platelet-activating factor acetylhydrolase: is it good or bad for you?Curr Opin Lipidol. 2004;15:337-341. PMID: 15166791. [IF=5.656; 7/60=11.7% in PERIPHERAL VASCULAR DISEASE]
Chang PY, Lu SC, Su TC, Chou SF, Huang WH, Morrisett JD, Chen CH, Liau CS, Lee YT. Lipoprotein-X reduces LDL atherogenicity in primary biliary cirrhosis by preventing LDL oxidation. J Lipid Res. 2004;45:2116-2122. [IF=4.421; 65/290=22.4% in BIOCHEMISTRY & MOLECULAR BIOLOGY]

2003

Chen CH*, Jiang T, Yang JH, Jiang W, Lu J, Marathe GK, Pownall HJ, Ballantyne CM, McIntyre TM, Henry PD, Yang CY. Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation. 2003;107:2102-2108. PMID: 12695302. [IF=15.073; 1/60=1.7% in PERIPHERAL VASCULAR DISEASE]
Yang CY, Raya JL, Chen HH, Chen CH, Abe Y, Pownall HJ, Taylor AA, Smith CV. Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arterioscler Thromb Vasc Biol.2003;23:1083-1090. PMID: 12689919. [IF=6.008; 4/60=6.7% in PERIPHERAL VASCULAR DISEASE]

2001

Chang PY, Luo S, Jiang T, Lee YT, Lu SC, Henry PD, Chen CH*. Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. Circulation. 2001;104:588-593. PMID: 11479258. [IF=15.073; 1/60=1.7% in PERIPHERAL VASCULAR DISEASE]

2000

Chen CH*, Jiang W, Via D, Luo S, Li TZ, Lee YT, Henry PD. Oxidized low-density lipoproteins inhibit endothelial cell proliferation by suppressing basic fibroblast growth factor expression. Circulation. 2000;101:171-177. PMID: 10637205. [IF=15.073; 1/60=1.7% in PERIPHERAL VASCULAR DISEASE]
Chen CH*, Volding D. Medicinal foods: cross cultural perspectives. In Food As A Drug, edited by Poston WSC. 2000. P. 49–64.

1999 and earlier

Chen CH*, Volding D. Medicinal foods: cross cultural perspectives. Drugs and Society. 1999;15:49-64.
Bucay M, Nguy J, Barrios R, Chen CH, Henry PD. Impaired adaptive vascular growth in hypercholesterolemic rabbit. Atherosclerosis. 1998;139:243-251. [IF=3.994; 11/60=18.3% in PERIPHERAL VASCULAR DISEASE]
Chen CH*, Cartwright J Jar, Li Z, Luo S, Nguyen HH, Gotto AM Jar, Henry PD. Inhibitory effects of hypercholesterolemia and oxidized LDL on angiogenesis-like endothelial growth in rabbit aortic explants: essential role of basic fibroblast growth factor. Arterioslcer Thromb Vasc Biol. 1997;17:1303-1312. [IF=6.008; 4/60=6.7% in PERIPHERAL VASCULAR DISEASE]
Chen CH*, Henry PD. Atherosclerosis as a microvascular disease: impaired angiogenesis mediated by suppressed basic fibroblast growth factor expression. Proc Assoc Am Physicians.1997;109:351-361.
Chen CH*, Nguyen HH, Weilbaecher D, Luo S, Gotto AM Jr, Henry PD. Basic fibroblast growth factor reverses atherosclerotic impairment of human coronary angiogenesis-like responses in vitro. Atherosclerosis. 1995;116:261-268. [IF=3.994; 11/60=18.3% in PERIPHERAL VASCULAR DISEASE]
Henry PD, Cabello OA, Chen CH. Hypercholesterolemia and endothelial dysfunction. Curr Opin Lipidol. 1995;6:190-195. [IF=5.656; 7/60=11.7% in PERIPHERAL VASCULAR DISEASE]
Chen CH*, Williams J, Lutherer LO. 1994. Cerebellar lesions alter autonomic responses to transient isovolemic changes in arterial pressure. Clin Auton Res. 1994;4:263-272.
Henry PD, Chen CH. Inflammatory mechanism of atheroma formation: influence of fluid mechanics and lipid-derived inflammatory mediators. Am J Hypertens. 1993;6(suppl):328-334. [IF=2.852; 25/60=41.7% in PERIPHERAL VASCULAR DISEASE]
Chen CH, O'Leary EL, Janssen HF, Lutherer LO. 1985. Changes in ambient temperature alter the blood pressure response to endotoxin and the effectiveness of naloxone. Circ Shock. 1985;16:185-193. PMID: 4053293.
Schoenfeld AD, Lox CD, Chen CH, Lutherer LO. Pain threshold changes induced by acute exposure to ambient temperature.Peptides. 1985;6 (suppl 1):19-22.
Lutherer LO, Smith AL, Chen CH, O'Leary EL, Lutherer BC. The effect of angiotensin and vasopressin blockade separately and in combination with cerebellectomy on recovery from hemorrhagic hypotension. Circ Shock. 1983;10:329-340. PMID: 6616765.
Chen L, Chen CH. Cardiac myxomas: a report of two cases. Modern Medicine in Asia. 1980;16(12), December.

presentations

*: Corresponding Author

†: Oral presentation

Ke LY†, Chan HC, Chen CC, Lu J, Marathe GK, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH*. O-Glycosylation of ApoB100 is associated with enhanced sphingomyelinase activity and atherogenicity of human electronegative LDL. To be presented at the American Heart Association Scientific Sessions in Orlando, FL, November 7–11, 2015.
Chou MC†, Cheng KH, Chu CS, Chang YH, Ke LY, Lai WT, Liu CK, Yang YH, Chen CH*. Statin Use is associated with a reduced risk of intracerebral hemorrhage recurrence: A population-based cohort study. To be presented at the American Heart Association Scientific Sessions in Orlando, FL, November 7–11, 2015.
Chu CS, Chan HC, Ke LY, Chan HC, Wang CY, Cheng KH, Lee HC, Kuo HF, Chang GT, Sheu SH, Sawamura T, Lai WT, Chen CH*. Electronegative LDL of metabolic syndrome patients induces release of inflammatory adipocytokines and accumulation of M1 macrophages in adipose tissue. Presented at the American Heart Association Scientific Sessions in Chicago, IL, November 15–19, 2014.
Chu CS, Ke LY, Chan HC, Chan HC, Chen CC, Cheng KH, Lee HC, Kuo HF, Chang GT, Sheu SH, Lai WT, Chen CH*. The four statin benefit groups defined by the 2013 ACC/AHA guideline are characterized by increased plasma level of electronegative LDL. Presented at the American Heart Association Scientific Sessions in Chicago, IL, November 15–19, 2014.
Chan HC, Ke LY, Chan HC, Su H, Lee AS, Lu J, Tsai WC, Ou TT, Wu CC, Chu CS, Shiea J, Yen JH, Chen CH*. Low-density lipoprotein of systemic lupus erythematosus patients contains lysophosphatidylcholine-rich lipid that induces overexpression of CX3CL1 in endothelial cells. Presented at the American Heart Association Scientific Sessions in Chicago, IL, November 15–19, 2014.
Hsu JF, Chou TC, Lu J, Elyasi M, Shayani S, Chen SH, Chen CH*. A novel total lipoprotein electronegativity index for predicting cardiometabolic risk. To be presented at the 2014 National Lipid Assciation Annual Scientific Sessions, Orlando, Florida, May 3, 2014.
Lee AS†, Chen WY, Chan HC, Shen MY, Wang YC, Lu LS, Lu J, Sawamura T, Chen CH*. Electronegative low-density lipoprotein induces endothelial DNA damage and senescence in vivo. Circulation. 2013;128:A12747. Presented at the American Heart Association Scientific Sessions in Dallas, TX, November 16–20, 2013.
Shen MY, Chen FY, Lee AS, Sheu JR, Sawamura T, Dixon RAF, Hsu CY, Chen CH*. Silencing miR-145 prevents potentiating effects of human electronegative low-density lipoprotein on platelet activation. Circulation. 2013;128:A12680. Presented at the American Heart Association Scientific Sessions in Dallas, TX, November 16–20, 2013.
Hsu JF†, Chou TC, Lu J, Chen SH, Shayani S, Chen CH*. A novel total lipoprotein electronegativity index for predicting cardiometabolic risk. Presented at the International Conference on Diabetes and Metabolism & 5th Scientific Meeting of the Asian Association for the Study of Diabetes in Seoul, Korea, November 6-9, 2013.
Hsu JF, Chou TC, Hsieh JY, Lu J, Chen SH, Shayani S, Chen CH*. A novel total lipoprotein electronegativity index for predicting cardiometabolic risk. Diabetes. 2013;62: A167. Presented at the American Diabetes Association 73rd Scientific Sessions in Chicago, Illinois, June 21-25, 2013.
Shen MY†, Sheu JR, Chen FY, Dixon RAF, Chen CH*. Electronegative LDL and beta-amyloid synergistically induce platelet activation that can be inhibited by novel microRNA-145 and NF-kB decoys. Presented at the American Heart Association-International Stroke Conference in Honolulu, Hawaii, February 6–8, 2013.
Chan HC†, Ke LY, Chu CS, Lee AS, Shen MY, Cruz MAC, Chan HC, Cheng KH, Lai WT, Yen JH, Sawamura T, Sheu SHS, Chen CH*.Highly Electronegative LDL is Elevated in Patients With Acute Myocardial Infarction and Triggers Platelet Activation and Aggregation. Circulation 2012;126:A9753. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
Wang YC, Lu LS, Dong JW, Lu J, Lee AS, Chen SH, Dou H, Kuzan TY, Chang KC, Dixon RA, Chen CH*. The DNA Damage Response Mediates Endothelial Cell Senescence Induced by Electronegative LDL. Circulation 2012;126:A16796. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
Lee AS, Chen FY, Chang SS, Pan CC, Chan HC, Chang CT, Su MJ, Chen CH*, Chang KC. Mechanisms of Cardiac Diastolic Dysfunction in a Model of Cardiorenal Syndrome. Circulation 2012;126:A12664. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
Chang KC, Wang YC, Chang SS, Lo PH, Lu J, Sawamura T, Lee YT, Burns AR, Chen CH*.Expression of the Highly Electronegative LDL Receptor LOX-1 is Increased in Thrombi of STEMI Patients. Circulation 2012;126:A13127. Presented at the American Heart Association Scientific Sessions in Los Angeles, CA, November 3–7, 2012.
Wang YC, Lu J, Chen SH, Dong JW, Huang RY, Dixon RAF, Elayda MA, Chen CH*. Electronegative low-density lipoprotein is increased early in cardiometabolic derangement. Published for the American Diabetes Association 72nd Scientific Sessions in Philadelphia, Pennsylvania, June 8-12, 2012.
Dong JW, Yilmaz HR, Lu J, Lu LS, Chen SH, Wang YC, Dixon RAF, Chen CH*. Mitochondrial damage by electronegative low-density lipoprotein in metabolic syndrome. Published for the American Diabetes Association 72nd Scientific Sessions in Philadelphia, Pennsylvania, June 8-12, 2012.
Chen CH*, Lu J, Dean J, Huang RY, Wang YC, Elayda MA, Dong JW, Chen SH, Dixon RAF. Mechanistic implication of electronegative low-density lipoprotein surge in acute myocardial infarction. J Am Coll Cardiol. 2012;59:E539. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
Lu J, Chu CS, Wang YC, Dong JW, Chen SH, Huang RY, Chen CH*. Electronegative low-density lipoprotein increases endothelial expression of C-reactive protein through LOX-1 receptor. J Am Coll Cardiol. 2012;59:E1472. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
Lee AS, Wang GJ, Chan HC, Chang KC, Chen FY, Chang CM, Yang CY, Chen CH*. Electronegative low-density lipoprotein induces cardiomyocyte apoptosis through a chemokine-cytokine crosstalk mechanism. J Am Coll Cardiol. 2012;59:E1000. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
Chang PY, Chen YJ, Yang TC, Lu SC, Chen CH*. Low-dose aspirin prevents coronary endothelial injury by oxidized-LDL through the Akt-FGF2 prosurvival pathway. J Am Coll Cardiol. 2012;59:E1726. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
Ma Y, Lu J, Cheng N, Wu G, Abbasi S, Cheng J, Chen CH, Xi Y. L5 induces cardiomyocytes damage and reduction of cardiac ATP-sensitive K+ Channels. J Am Coll Cardiol. 2012;59:E1055. Presented at the 61st American College of Cardiology Scientific Sessions in Chicago, IL, March 24–27, 2012.
Chen CH*, Lu J, Engler DA, Ke LY, Yilmaz HR, Dixon RAF, Chen SH, Yang CY. Biologic Significance of Charge-Based Heterogeneity in Diabetic VLDL Subfractions. Diabetes. 2011;60(Suppl 1):A157. Presented at the American Diabetes Association 71st Scientific Sessions in San Diego, California, June 24-28, 2011.
Cheng N, Lu J, Sun J, Wu G, Abbasi S, Zhang J, Cheng J, Chen CH, Xi Y. Most negatively charged subfraction (l5) of plasma ldl prolongs action potential duration of rat cardiomyocytes via LOX-1 receptors. J Am Coll Cardiol. 2011;57:E58. Presented at the 60th American College of Cardiology Scientific Sessions in New Orleans, LA, April 2–5, 2011.
Dixon RAF, Lu J, Chen CH.Negatively charged LDL subfraction contributes to both atherosclerosis and hypertension in type 2 diabetes. 3rd World Congress on Controversies in Diabetes, Obesity and Hypertension. Prague, Czech Republic. May 13-16, 2010.
Chen CH*, Lu J, Wang GJ, Dixon RAF, Yang CY, Willerson JT. Mechanistic basis of L5 as a novel treatment target for coronary artery disease. 8th International Congress on Coronary Artery Disease. Prague, Czech Republic. October 11–14, 2009.
Chang PY, Lee JK, Chen YJ, Lu SC, Lee YT, Chang KC, Pai PY, Chen CH. Identification of an electronegative LDL as potential novel biomarkerfor acute coronary syndrome. European Society of Cardiology Congress. Barcelona, Spain. August 29–September 2, 2009.
Tang D†, Burns AR, Lu J, Chen HH, Wu H, Morrisett JL, Sawamura T, Yang CY, Chen CH*. Electronegative LDL disrupts mitochondrial homeostasis: a novel mechanism for cigarette smoking-associated endothelial dysfunction. FASEB J. 2008 22:Presented at the FASEB2008 meeting, San Diego, CA, April 5–9, 2008.
Tang D†, Chen HH, Lu J, Engler DA, Sawamura T, Pownall HJ, Yang CY, Chen CH*. Chronic smoking-yielded electronegative LDL induces MEK/ERK mediated metalloproteinase activation in human endothelial progenitor cells. J Am Coll Cardiol. 2008;51(suppl A):A278. Presented at the American College of Cardiology 2008 Scientific Sessions, Chicago, IL, March 29–April, 2008.
Tang D†, Lu J, Walterscheid JP, Chen HH, Yang JH, Engler DA, Sawamura T, Marcelli M, Yang CY, Chen CH*. Electronegative LDL in smoking subjects inhibits endothelial progenitor cell differentiation by impairing Akt phosphorylation via the LOX-1 receptor. Arterioscler Thromb Vasc Biol. 2007; Presented at the ATVB Annual Conference April 19-21, 2007 Chicago, IL.
Lu J, Walterscheid JP, Chen HH, Yang CY, Poucher SM, Chen CH*. Diabetic LDL subfraction induces smooth muscle cell proliferation by enhancing endothelial release of endothelin-1. Diabetes. 2006;55 (suppl 1):A160. Presented at the American Diabetes Association 66th Scientific Sessions in Washington DC. June 9–13, 2006.
Lu J, Chen HH, Yang CY, Walterscheid JP, Pownall HJ, Morrisett JD, Chen CH*. C4 Platelet-activating factor mimics electronegative LDL circulating in patients with metabolic syndrome in inducing endothelial cell apoptosis. Diabetes. 2005;54(suppl 1):A193. Presented at the American Diabetes Association 65th Scientific Sessions in San Diego, CA, June 10–14, 2005.
Lu J, Yang JH, Chen HH, Yang CY, Henry PD, Walterscheid JP, Morrisett JD, Sawamura T, Chen CH*. Effective attenuation of electronegative LDL-induced endothelial cell apoptosis by gene silencing of the lectin-like receptor for oxidized LDL. J Am Coll Cardiol. 2005. Presented at the 54th American College of Cardiology Scientific Sessions in Orlando, FL, March 6–9, 2005.
Tai MH, Kuo SM, Huang MT, Yang JH, Chen HH, Lu J, Sawamura T, Chen CH, Yang CY. Activation of caspase 13 by diabetic electronegative LDL through lectin-like oxidized LDL receptor-1 (LOX-1) in vascular endothelial cells. Circulation. 2005;112:II-1105. Presented at the American Heart Association 2005 Scientific Sessions, Dallas, TX, November 11-16, 2005.
Chang PY, Lu SC, Lee CM, Huang WH, Chen YJ, Liao WSL, Chen CH, Lee YT. Homocysteine impairs endothelial cell survival by repressing the transcriptional activity of the fibroblast growth factor 2 promoter. J Am Coll Cardiol. 2005. Presented at the 54th American College of Cardiology Scientific Sessions in Orlando, FL, March 6–9, 2005.
Lu J, Marcelli M, Liao WSL, Yang JH, Henry PD, Yang CY, Pownall HJ, Chen CH*. Dominant-negative Akt impairs endothelial cell survival by mimicking the inhibitory effect of electronegative LDL on FGF2 transcription. Circulation. 2004;110-III87. Presented at the American Heart Association 2004 Scientific Sessions, New Orleans, LA, November 7-10, 2004.
Chen CH*, Pace PW, Karakoc ND, Lu J, Chen HH, Henry PD, Pownall HJ, Foreyt JP, Ballantyne CM, Yang CY. Effective reduction of novel atherogenic LDL subfraction by atorvastatin in patients with hypercholesterolemia. J Am Coll Cardiol. 2004;43(suppl A):486A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
Lu J, Chen HH, Suzuki S, Yang CY, Henry PD, Sawamura T, Chen CH*. Role of the LOX-1 receptor in transducing the apoptotic signals of circulating atherogenic LDL. J Am Coll Cardiol. 2004;43(suppl A):26A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
Jiang W, Lu J, Yang JH, Chang PY, Lee YT, Marcelli M, Henry PD, Liao WSL, Chen CH*. Atherogenic LDL impairs vascular endothelial cell survival by disrupting the FGF2-PI3K-Akt autoregulatory loop. J Am Coll Cardiol. 2004;43(suppl A):499A. Presented at the 53rd American College of Cardiology Scientific Sessions in New Orleans, LA, March 7–10, 2004.
Lu J, Marathe GK, Yang CY, Jiang W, Yang JH, Pownall HJ, Henry PD, Chen CH*. Platelet-activating factor-like lipids mediate endothelial cell apoptosis induced by hypercholesterolemic LDL. J Am Coll Cardiol. 2003;41(Supple):243A. Presented at the 52nd American College of Cardiology Scientific Sessions in Chicago, IL, March 30–April 2, 2003.
Chen CH*, Jiang T, Yang JH, Jiang W, Pownall HJ, Ballantyne CM, Lu J, Henry PD, Yang CY. Induction of vascular endothelial cell apoptosis through the platelet-activating factor receptor in hypercholesterolemia. Atherosclerosis. 2002;3:88. Presented at the 73rd European Atherosclerosis Society Congress, Salzburg, Austria, July 7-10, 2002.
Lu J, Suzuki S, Safi HJ, Jiang W, Henry PD, Yang JH, Morrisett JD, Chen CH*. OxLDL LDL-induced vascular endothelial cell apoptosis involves ceramide-mediated Akt dephosphorylation: protective role of FGF2 overexpression. Atherosclerosis. 2002;3:88. Presented at the 73rd European Atherosclerosis Society Congress, Salzburg, Austria, July 7-10, 2002.
Jiang W, Lu J, Chang PY, Yang JH, Henry PD, Marcelli M, Chen CH*. Oxidized LDL induces endothelial cell apoptosis by impairing the FGF2-PI3K-Akt pathway. Circulation. 2002;105:e86-e119. Presented at the American Heart Association-Asia Pacific Scientific Forum, Honolulu, Hawaii, April 23-26, 2002.
Lu J, Suzuki S, Safi HJ, Jiang W, Henry PD, Yang CY, Chen CH*. FGF2 overexpression prevents ceramide-mediated Akt deactivation in endothelial cells exposed to oxidized LDL. Arterioscler Thromb Vasc Biol. 2002;22:878-a. Presented at the American Heart Association-3rd Annual ATVB council meeting, Salt Lake City, Utah, April 6-8, 2002.
Chen CH*†, Yang JH, Morrisett JD, Lu J, Jiang T, Henry PD, Yang CY. Proapoptotic activity of a novel LDL subfraction in hypercholesterolemic human plasma. Circulation. 2001;104:II297. Presented at AHA 2001 Scientific Sessions 2001 of the American Heart Association, Anaheim, CA, November 11-14, 2001.
Chen CH*, Yang JH, Luo S, Chang PY, Gross R, Wu S, Henry PD. Oxidized LDL-induced endothelial cell apoptosis: role of mediator phospholipids and bFGF. Atherosclerosis. 2000;151:215. Presented at the XIIth International Symposium on Atherosclerosis, Stockholm, Sweden, June 25-29, 2000.

lectures

A lipid maze to cell senescence. Boston Taiwanese Biotechnology Association, Massachusetts Institute of Technology, Boston, MA, USA. October 7, 2015.
A lipid maze to cell senescence. Institute of Biomedical Sciences, Academia Sinica, Taipei Taiwan. October 28, 2015.
Role of electronegative lipoproteins in cell senescence. Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan. July 7, 2015.
From Lipids to Glycans, and Vice Versa. Symposium on “RECENT ADVANCE IN VASCULAR BIOLOGY”, Taiwan Society of Cardiology. Taipei, Taiwan. May 23, 2015.
From Glycans to Lipids and Vice Versa. Seminar Series, Department of Biomedical Engineering, Texas A&M University, College Station, Texas. April 22, 2015
Role of glycan-LDL interactions in inflammation. Grand Round, Cardiology Department, Taichung Veterans General Hospital, Taichung, Taiwan. April 10, 2015.
Modulation of glycobiology by atherogenic LDL. International symposium: New Era of Lipid and Glycomedicine Research. Kaohsiung Medical University, Kaohsiung, Taiwan, March 23, 2015.
From Glycans to Lipids and Vice Versa. Grand Round. Changhua Christian Hospital Systems, Changhua, Taiwan, January 30, 2015
Role of Lipid-Glycan Interaction in Vascular Aging. Department of Medicine Grand Round, Tzu Chi Medical School and Hospital, Hualien, Taiwan, December 23, 2014.
L5 LDL, a novel target of treatment for heart attacks, stroke, and dementia? National Yang Ming University, Taipei, Taiwan, December 5, 2014.
What the tiny lipid molecules can do to harm our heart and brain: an update on lipid research at KMU. 2014 KMUAAA Conference, Las Vegas, Nevada, September 27, 2014.
Electronegative lipoproteins: Unhealthy liver products that damage all body systems. International Symposium for Hepatitis C. Kaohsiung Medical University, Kaohsiung, Taiwan, June 20, 2014.
LDL and HDL: Particle size, charge, and beyond. Manhattan Project-Coronary Atherosclerosis Research Symposium. Mount Sinai Medical Center and New York Heart Research Foundation, New York, New York, June 7, 2014.
Role of miRNAs in LDL-enhanced platelet aggregation in stroke. James T Willerson MD Cardiovascular Seminar, Texas Heart Institute, Houston, Texas, May 15, 2014,
Thrombotic LDL and dysfunctional HDL in acute myocardial infarction. Keynote speech. East Taiwan Cardiology Symposium. Tzu Chi Medical Center, Hualien, Taiwan, April 19, 2014.
Impact of increased lipoprotein electronegativity on atherogenicity. Visiting Scholar Lectureship. Division of Cardiology, Department of Medicine, UT Southwestern Medical Center, Dallas, Texas, March 26, 2014.
Electronegative LDL and genome/microRNA sequencing. Molecular Diagnostic Laboratory, Baylor College of Medicine, Houston, Texas, February 26, 2014.
Biological Significance of Electronegative Lipoproteins: Future Perspectives of Cardiovascular Research at KMU and KMUH. 2013 KMUAAA Conference, San Jose, CA, August 17, 2013.
Methods for removing toxic components of electronegative LDL from the plasma. Industrial Technology Research Institute, Hsinchu, Taiwan, May 8, 2013.
Biological significance of electronegative lipoproteins. School of Medicine, Tzu Chi University, Hualien, Taiwan, May 3, 2013.
Chemical, molecular, and in vivo evidence of L5 as circulating atherogenic LDL. Center for Translational Cancer Research, Institute of Biosciences and Technology (IBT), Texas A&M Health Science Center, Houston, Texas, March 11, 2013.
Electronegative LDL Increases Cardiac Arrhythmogenicity by Activating CaMKII and Suppressing ATP-Sensitive Potassium Channels. Asia Pacific Heart Rhythm Society 2012 (APHRS2012), Taipei, Taiwan, October 3-6, 2012.
Cardiovascular Implications of L5: A New Focus of Treatment. The Mount Sinai Hospital, New York, NY, July 19, 2012.
Cardiovascular Implications of L5: A New Focus of Treatment. New York Heart Research Foundation, New York, NY, July 17, 2012.
Surge of Electronegative LDL in Acute MI: A new focus of Treatment. Cardiovascular Basic Science Seminar of Texas Heart Institute, Baylor College of Medicine, and UT-Houston Medical School, in Houston, TX, October 27, 2011.
Identification of V5, the electronegative and atherogenic VLDL subfraction, in metabolic syndrome. Merck Pharmaceuticals Research Group, at the American Diabetes Association 71st Scientific Sessions in San Diego, CA, June 25, 2011.
L5 and Vascular Pathology, on Symposium: New Frontier in Diagnosis and Management of CV Disease in 2010, for 30th Anniversary of CMUH, China Medical University Hospital-Taiwan, Taichung, Taiwan, November 21, 2010. (Post-symposium invited publication: Asian J Health Sciences 2011 – see Publication)
Unique chemical characteristics of naturally occurring atherogenic LDL. 11th Eurasia Conference on Chemical Sciences (EuAsC₂S-11), Dead Sea, Jordan, October 6–10, 2010. (Post-symposium invited publication: Pure Appl Chemistry 2011 – see Publication)
L5: A potential novel treatment target for diabetic vasculopathy. International Symposium on Integrative Approaches in the Battle Against Diabetes, Kangwon National University, Chunchon, Korea, September 9, 2010.
Potential Link between L5 and Stroke. Neurology and Neurosurgery combined Grand Round, China Medical University Hospital-Taiwan, Taichung, Taiwan, June 9, 2010.
L5—Our new direction. Kaohsiung Medical University Hospital Cardiovascular Science Symposium 2009, Kaohsiung, Taiwan, December 20, 2009.
When LDL becomes negatively charged.Graduate Institute of Biomedical Sciences, Chang Gung University, Seminar Series, Taipei, Taiwan, December 18, 2009.
When “bad cholesterol” takes a further negative spin. THI/UT/MDACC Cardiovascular Research Seminar Series, Houston, Texas, December 3, 2009.
Mechanism of L5 formation stimulated by chronic smoking. Philip Morris International Research Center at Leuven, Belgium, October 16, 2009.
Smoker L5 induced endothelial dysfunction. Philip Morris International Research Center at Cologne, Germany, October 15, 2009.
Cardiovascular Disease & Stroke Cardiovascular Conference: Mechanistic basis of L5 as a novel treatment target for coronary artery disease. Texas Tech University Health Sciences Center. Lubbock, Texas, August 20, 2009.
Topnotch Research Projects Strategic Conference: L5 as a causative factor for and marker of coronary artery disease. China Medical University Hospital, Taichung, Taiwan, July 15, 2009.
Targeted prevention of tobacco-associated atherosclerosis. Philip Morris International Special Lecture Invitation. Neuchatel, Switzerland, May 27, 2009.
Atherosclerosis and Vascular Biology Training Center Research Seminar Series, Baylor College of Medicine, Houston, Texas; October 9, 2008: L5—Functional properties and clinical implications
The 26th World Chinese Trader Convention, Special Lecture Series, New York, New York; September 14, 2008: Electronegative LDL—A new mechanism and treatment target for cardiovascular disease
Cardiovascular Basic Science Seminar, Baylor College of Medicine, Houston, Texas; September 9, 2008: Electronegative LDL—What is it, who has it, what does it do to you?
The 8th Annual Emerging Information and Technology Conference (EITC-2008), National Cheng Kung University, Tainan, Taiwan; June 26–27, 2008. Invited lecture: New mediators of smoking-incurred endothelial progenitor dysfunction
Institutional Grand Round, National Research Institute of Chinese Medicine, Taipei, Taiwan; June 24, 2008: Why is Smoking Bad for You? New Clues to an Old Enigma
Cardiology Section Grand Round, Chang-Gung Memorial Hospital, Taipei, Taiwan; June 23, 2008: Why is Smoking Bad for You? New Clues to an Old Enigma
Department of Medicine Grand Round, China Medical University, Taichung, Taiwan; June 20, 2008: Atherogenicity of Electronegative LDL—New Mechanism of Smoking-Incurred Endothelial Progenitor Dysfunction
American Heart Association, Western Review Consortium Study Group 4A Grant review meeting; Los Angele, California, April 15-16, 2008
1st International Conference on Drug Design and Discovery, Dubai, UAE; February 4-7, 2008. Session Lecture: New drug development following characterization of a novel atherogenic lipoprotein
The Seventh Annual Emerging Information and Technology Conference (EITC-2007), Princeton University, New Jersey; June 9-10, 2007. Invited speech: The potential anticancer effects of electronegative LDL, a biological nanoparticle
Kaohsiung Medical University Hospital 50th Anniversary Cardiovascular Symposium, Kaohsiung, Taiwan; June 10, 2007, Keynote Speech: Structural characterization and signal mapping of electronegative LDL
American Heart Association, Western Review Consortium Study Group 4A Grant review meeting; Houston, Texas; April 18-19, 2007
2006 World Congress of Internal Medicine, November 10-13, 2006, Taipei, Taiwan; Symposium: Hyperlipidemia and Cardiovascular Diseases: Clinical Challenge in IT Era; Invited Lecture: New Strategies of LDL Lowering: From Bench to Clinical Work
The Sixth Annual Emerging Information Technology Conference (EITC-2006), University of Texas at Dallas, Dallas, Texas; August 10-11, 2006. Invited speech: What is L5, a recently discovered biological nanoparticle, and how does it affect your health?
Department of Molecular and Cellular Oncology, UT-MD Anderson Cancer Center, Houston, Texas; May 31, 2006. Invited seminar: L5, a circulating lipoprotein that erodes your arteries
American Heart Association, Western Review Consortium Study Group 4A Grant review meeting; Salt Lake City, Utah,; April 18-19, 2006
Atorvastatin Research Award (ARA) Summit Meeting, February 10-12, 2006, Salt Lake City, Utah; Invited speech: Introductory Talk for the Summit: The ARA and My Career Development

Ad hoc reviewers

American Journal of pathology
Apoptosis
Archivum Immunologiae et Therapiae Experimentalis
Arteriosclerosis, Thrombosis, and Vascular Biology
Blood
British Journal of Pharmacology
Cardiovascular Diabetology
Circulation Research
Circulation
Diabetes
Diabetes Care
International Journal of Molecular Sciences
Journal of Translational Medicine
Molecular Pharmaceutics
PLOS One
THI Journal

前端編輯

陳珠璜 主任/教授 (Chu-Huang Chen)

publications

KMU LSARC

陳珠璜主任/教授 (Chu-Huang Chen)