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Issues of critical importance

Abnormal lipids and cognitive impairment: Several lines of evidence suggest that cholesterol metabolism plays an important role in pathophysiology of demetia, suhc as AD. However, so far the association between L5 and pathogenesis of AD remains unknown. Our hypothesis is that L5 may cause injury or dysfunction of the BBB to enhance the possibilty of  neurotoxicity by L5 itself or other toxins. A key point in our research is to determien the role of L5 in AD pthogeneiss, including converion of MCI to AD or severe dementia. Another approach is to examine the synergistic effects of L5 and Ab on Ab-mediated cerebral angiopathy, a pattern of vascular dementia secondary to lucunar strokes. A target of interest is platelets. By activating the NF-kB, the L5-Ab duo can induce platelet aggregation precipitating to ischemic strokes. A novel therapeutic method invloing interfering miR-regulated sugnaling is also being developed.

Molecular mechanisms of high glucose and L5 cause cognitive decline and neuropathy:We aim to investigate the role of inflammatory mediators and macrophage polarization in cognitive decline among diabetic patients and its pathogenesis, investigate the role of electronegative low-density lipoprotein in cognitive decline and its pathogenesis in neurodegenerative diseases including Alzheimer’s disease and persistent hyperglycemia dys-regulates sodium channels expression in sensory and sympathetic ganglion neurons.

 

 

團隊一、腦神經系統劉景寬 醫學系/高醫附院腦神經內科 教授/校長
 賴秋蓮 醫學系/高醫附院腦神經內科 教授
 程廣義 醫學系/高醫附院麻醉科 主任/副教授
 王志煜 高雄醫學大學神經學科碩士班 助理教授
 洪志興 高醫大/小兒部 教授
 謝正芳 醫學系/高醫附院腦神經內科 主治醫師
 陳俊鴻 醫學系/高醫附院腦神經內科 助理教授/醫師
 周美娟 醫學系/高醫附院腦神經內科 助理教授/醫師
 劉立民 高雄市立小港醫院 主治醫師
 陳秀蘭 高雄醫學大學神經學科碩士班 助理教授
 吳世忠 醫技系 助理教授
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