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肝臟系統 (Hepatic System)

Non-alcoholic fatty liver disease (NAFLD) has become an emerging epidemic globally. We have conducted serial genetic studies aiming to elucidate the underlying pathogenic mechanisms. We demonstrated that mt12361G carriers have a greater risk for moderate and severe NAFLD. These results provided some insights regarding the genetic predisposition to NAFLD in the general population. (Transl Res 2012;159:58-9.)

The adiponutrin/patatin-like phospholipase-3 (PNPLA3) I148M polymorphism has recently been found to contribute to differences in hepatic lipid content. We therefore conducted a case-control study aiming to clarify the relationship between NAFLD and the PNPLA3 genotype in a normoglycaemic population. We found significant differences in the genotype and the dominant model of the PNPLA3 I148M polymorphism between the NAFLD groups and the controls. Furthermore, there was a dose effect of the PNPLA3 I148M genotype, in that CG heterozygotes had a risk of NAFLD between CC and GG homozygotes. Our results shed a light on the genetic predisposition of development of NAFLD (Liver Int 2011;31:1326-31.)

 

團隊五、肝臟系統 余明隆 醫學系/高醫附院肝膽內科 教授/醫師
莊萬龍 醫學系/高醫附院肝膽內科 教授/醫師
戴嘉言 醫學系/高醫附院肝膽內科 教授/醫師
黃志富 醫學系/高醫附院肝膽內科 教授/醫師
黃釧峰 高醫肝膽胰內科 主治醫師
林宜竑 高醫肝膽胰內科 主治醫師
葉明倫 高醫肝膽胰內科 主治醫師
謝明彥 高醫肝膽胰內科 主治醫師
黃駿逸 高醫肝膽胰內科 主治醫師
謝孟軒 醫學院醫學系 助理教授
柯佑民 高醫肝膽胰內科 博後
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