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【專題演講】9月24日(四)上午9:30「Engineered HSCs Confer Multipotentiality and Reconstitute Adaptive Immunity」 

主題:Engineered HSCs Confer Multipotentiality and Reconstitute Adaptive Immunity 
日期:104年09月24日(星期四) 09:30a.m. ~10:30a.m. 
地點:勵學大樓2 F第一會議室 

內容說明: 
      本中心擬於104年9月24日(星期四)上午9時30分至上午10時30分於本校勵學大樓2F第一會議室,舉 辦專題演講,並邀請
哈佛大學兒童醫院博士後研究員呂宜棻博士進行演講及學術交流指導。竭誠歡迎大家 蒞 臨參加,提供您們寶貴意見。 

Summary of lecture 
      Hematopoietic stem cell (HSC) transplantation is curative for malignant and genetic blood disorders, but is limited by donor availability and immune mismatch. Deriving HSCs from patient-matched embryonic/pluripotent stem cells (ESC/PSCs) could address these limitations. Prior efforts in a murine model system have exploited enforced expression of hoxb4 to drive self-renewal and enable multi-lineage reconstitution of irradiated hosts by ESC-HSCs, yet fell short in delivering robust lymphoid engraftment. Analysis of the gene regulatory networks of hoxb4-ESC-HSC revealed a deficiency in targets of the Notch signal transduction pathway. Here, by titrating exposure of hoxb4-ESC-HSC to Notch ligands, we report derivation of engineered HSCs that self-
renew, repopulate multi-lineage hematopoiesis in primary and secondary engrafted mice, and endow adaptive immunity in immune-deficient recipients. Single cell analysis shows that following engraftment in the bone marrow niche, these engineered HSCs further specify to a hybrid cell-type in which distinct gene regulatory networks of hematopoietic stem/progenitors and differentiated hematopoietic lineages are co-expressed. Our work demonstrates engineering of fully functional HSCs via modulation of genetic programs that govern self-renewal (via HoxB4) and lineage priming (via Notch pathway activation). 

演講時間、地點 
  日    期:104年09月24日(星期四) 09:30~10:30 
  地    點:勵學大樓 2F 第一會議室 
                (高雄市三民區十全一路100號) 
  主辦單位:高雄醫學大學–脂質科學暨老化研究中心 
  聯絡人:脂質科學暨老化研究中心 / 詹秀娟 
  聯絡電話 07-3121101轉2294 
  E-mail: lsarc@kmu.edu.tw 

 

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