09/1992 to 06/1999 Kaohsiung Medical College. Medical doctor


09/2003 to 06/2005  Kaohsiung Medical University. Master of Medical Science


09/2008 to 06/2016  Graduate Institute of Medicine, Kaohsiung Medical University. Ph.D.

08/2010 to 07/2012  Visiting scholar, Cardiac Bioelectricity and Arrhythmia Center, Biomedical Engineering Department, Washington University in St. Louis, USA


Employment Records


08/1999 to 07/2002 Resident, Department of Internal Medicine, Kaohsiung Medical University Hospital


08/2002 to 07/2004  Fellowship in Cardiology, Kaohsiung Medical University Hospital


08/2004 to 06/2006  Attending Physician, Municipal Hsiaokang Hospital, Kaohsiung, Taiwan


07/2006 to 07/2007  Attending Physician, Municipal Pingtung Hospital, Department of Health, Taiwan


08/2004 to present  Attending cardiologist, Kaohsiung Medical University Hospital

02/2014 to present  Assistant professor, College of Medicine, Kaohsiung Medical University


Professional Affiliations

Member of the Taiwan Society of Internal Medicine

Member of the Taiwan Society of Cardiology

Member of the Taiwan Hypertension Society

Member of the Taiwan Society of Ultrasound in Medicine

Member of the Taiwan Society of Critical Care Medicine

International Fellow of American Heart Association

Member of Biophysical Society

Member of Taiwan Society of Lipids & Atherosclerosis




  1. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic beta cells.Lee CH, Chu CS, Tsai HJ, Ke LY, Lee HC, Yeh JL, Chen CH and Wu BN.  Chem Biol Interact. 2018;279:171-176.
  2. Association between modified CHA2DS2-VASc Score with Ankle-Brachial index < 0.9.Hsu PC, Lee WH, Lee HC, Tsai WC, Chu CY, Chen YC, Lee CS, Lin TH, Voon WC, Sheu SH, and Su HM.  Sci Rep. 2018 Jan 19;8(1):1175.
  3. High fat diet aggravates atrial and ventricular remodeling of hypertensive heart disease in aging rats.

  4. YL Shiou, IC Huang, HT Lin, HC Lee*. JFMA 2018 Jul;117(7):621-631. 2017 Sep (E-pub)

  5. Range of L5 LDL levels in healthy adults and L5's predictive power in patients with hyperlipidemia or coronary artery disease.Chu CS, Chan HC, Tsai MH, Stancel N, Lee HC, Cheng KH, Tung YC, Chan HC, Wang CY, Shin SJ, Lai WT, Yang CY, Dixon RA, Chen CH, Le LY.  Sci Rep. 2018 Aug 8;8(1):11866.
  6. Simultaneous Electrocardiography Recording and Invasive Blood Pressure Measurement in Rats.Lin HT, Shiou YL, Jhuang WJ, Lee HC*.  JoVE-Journal of Visualized Experiments. 2018 In Press.


  1. Pro-arrhythmogenic effects of the V141M KCNQ1 mutation in short QT syndrome and its potential therapeutic targets - insights from modeling.Lee HC, Rudy Y, Liang H, Chen CC, Luo CH, Sheu SH, Cui J.  J Med Biol Eng. 2017 Oct;37(5):780-789. 2017 Jul (Epub)
  2. Very-low-density lipoprotein of metabolic syndrome modulates gap junctions and slows cardiac conduction.HC Lee, CC Chen, WC Tsai, HT Lin, YL Shiao, SH Sheu, BN Wu, CH Chen, WT Lai.  Sci Rep. 2017 Sep 21;7(1):12050.
  3. Electronegative low-density lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.Ke LY, Chan HC, Chan HC, Kalu FCU, Lee HC, Lin IL, Jhuo SJ, Lai WT, Tsao CR, Sawamura T, Dixon RA, Chen CH, Chu CS, Shin SJ.  J Clin Endocrinol Metab. 2017 Dec 1;102(12):4615-4625. doi: 10.1210/jc.2017-01657.
  4. Air pollution particular matter and atherosclerosis.Lee HC, Lin TH.  Acta Cardiol Sin. 2017 Nov; 33(6): 646–647.


  1. VLDL from metabolic syndrome individuals enhanced lipid accumulation in atria with association of susceptibility to atrial fibrillation.Lee HC, Lin HT, Ke LY, Wei C, Hsiao YL, Chu CS, Lai WT, Shin SJ, Chen CH, Sheu SH, Wu BN.  Int J Mol Sci. 2016;17:134.
  2. Areca nut chewing complicated with non-obstructive and obstructive ST elevation myocardial infarction.Chen YC, Lee HC, Lee HH, Su HM, Lin TH and Hsu PC.  Acta Cardiologica Sinica. 2016;32:103-7.
  3. Four statin benefit groups defined by the 2013 ACC/AHA new cholesterol guideline are characterized by increased plasma level of electronegative LDL.Chu CS, Ke LY, Chan HC, Chan HCB, Chen CC, Cheng KH, Lee HC, Kuo HF, Chang CT, Chang KC, Sheu SH, Chen CH, Lai WT.  Acta Cardiol Sin. 2016;32:667-675
  4. Modulation of potassium channel KCNQ1 transcript in right atrial appendage of patients with postoperative atrial fibrillation.Lee HC, Chiu CC, Chen CC, Huang JW, Lin HT, Hsiao YL, Sheu SH, Hsieh CC.  Int J Cardiol. 2016;222, p696–698 (published online: August 4, 2016)


  1. Fulminant dengue myocarditis complicated with profound shock and fatal outcome under intra-aortic balloon pumping support. Lin TC, Lee HC, Lee WH, Su HM, Lin TH, Hsu PC. Am J Emerg Med. 2015 Mar 18. pii: S0735-6757(15)00183-7.


  1. Coronary collateral circulation in patients of coronary ectasia with significant coronary artery disease. Hsu PC, Su HM, Lee HC, Juo SH, Lin TH, Voon WC, Lai WT, Sheu SH. PLoS One. 2014 Jan 27;9(1):e87001.


  1. Reply to the editor- amiloride concentrations in clinical practice. Lee HC, Rudy Y, Cui J. Heart Rhythm. 2013 Nov;10(11):e83.
  2. Psychometric testing of the properties of the spiritual health scale short form. Hsiao YC, Chiang YC, Lee HC, Han CY. J Clin Nurs. 2013 Nov;22(21-22):2981-90.
  3. Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization. Lee HC, Rudy Y, Po-Yuan P, Sheu SH, Chang JG, Cui J. Heart Rhythm. 2013 Aug;10(8):1220-8.
  4. Barriers to research utilization by registered nurses in Taiwan. Chen SH, Shao JH, Hsiao YC, Lee HC. Res Nurs Health. 2013 Apr;36(2):191-202.


  1. The effects of a spiritual learning program on improving spiritual health and clinical practice stress among nursing students. Hsiao YC, Chiang HY, Lee HC, Chen SH. J Nurs Res. 2012 Dec;20(4):281-90.
  2. Impact of short-duration administration of N-acetylcysteine, probucol and ascorbic acid on contrast-induced cytotoxicity. Lee HC, Sheu SH, Liu IH, Lee CC, Hsieh CC, Yen HW, Lai WT, Chang JG. J Nephrol. 2012 Jan-Feb;25(1):56-62.


  1. Ionic contrast media induced more apoptosis in diabetic kidney than nonionic contrast media. Lee HC, Chang JG, Yen HW, Liu IH, Lai WT, Sheu SH. J Nephrol. 2011 May-Jun;24(3):376-80.


  1. Mismatch between arterial stiffness increase and left ventricular diastolic dysfunction. Hsu PC, Lin TH, Lee CS, Lee HC, Chu CY, Su HM, Voon WC, Lai WT, Sheu SH. Heart Vessels. 2010 Nov;25(6):485-92.
  2. Acute carbon monoxide poisoning resulting in ST elevation myocardial infarction: a rare case report. Hsu PC, Lin TH, Su HM, Lee HC, Huang CH, Lai WT, Sheu SH. Kaohsiung J Med Sci. 2010 May;26(5):271-5.
  3. JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis. Lee HC, Sheu SH, Yen HW, Lai WT, Chang JG. Am J Nephrol. 2010;31(2):125-33.


  1. Myocardial performance index derived from brachial-ankle pulse wave velocity: a novel and feasible parameter in evaluation of cardiac performance. Su HM, Lin TH, Lee CS, Lee HC, Chu CY, Hsu PC, Voon WC, Lai WT, Sheu SH. Am J Hypertens. 2009 Aug;22(8):871-6.
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